The common bean culture has a high-cost production system, mainly due to the use of inputs such as nitrogenous fertilizers and soil phytopathogen control with fungicide applications. An alternative for reducing and/or replacing the use of nitrogenous fertilizers and reducing fungicide use while continuously increasing crop productivity is the technique of co-inoculation with nitrogen-fixing and growth-promoting bacteria. One of the major challenges of using liquid inoculants in the culture is the low survival of Rhizobium tropici in these formulations. The objective of the thesis is to develop polymeric inoculants with high cell survival and a six-month shelf life containing Rhizobium tropici and selected strains of growth-promoting bacteria with biocontrol activity against diseases for application in common beans. In this context, it is necessary to understand and address some questions regarding their respective themes, which are as follows: 1st theme: agricultural potential of microorganisms and efficiency of inoculants for common bean (1-Considering that the goal of your work is to propose a new product composed from the combination of microorganisms for the cultivation of common beans in liquid formulation: a. What are the main types of microorganism formulations, emphasizing the main advantages and disadvantages; b. Describe the necessary steps for the registration of this product in MAPA so that it can be produced and marketed; c. Make a survey of the main products based on plant growth promoting microorganisms registered in MAPA, emphasizing the microorganisms present in the product, the main attributes of plant growth promotion and the crop for which it is intended and; 2- Comment on the pros and cons, from the agronomic, commercial and manufacturing production points of view, of the use of two or more microorganisms in the co-inoculation of common bean and 3- In your opinion, what should the inoculants for common bean deliver so that the use of biological inputs in the crop increases significantly?) and 2nd theme: ways of studying the interaction between plant and microorganism and its benefits (1- Survey the studies on the bean microbiome, with emphasis on amplicon sequencing and metagenomics and critically discuss how this microbiome can benefit the crop and; 2- Describe possible biological control mechanisms that plants perceive when inoculated with beneficial bacteria. Detail the mechanisms and methods used to evaluate this gene induction in the plant). Regarding the 1st theme, the use of inoculants is an alternative to the use of fertilizers, due to promoting the same effect, with high production and economic benefits, making agriculture more sustainable. Inoculants containing bacteria that promote plant growth, also known as biofertilizers, is one of the main biotechnologies that improve the efficiency of use and/or the total replacement of synthetic fertilizers. This group of rhizobia act through the main mechanism of action of agricultural interest, biological nitrogen fixation (BNF), as well as other microorganisms act with other direct and indirect mechanisms that have potential for the formulation and production of inoculants, known as Plant Growth Promoting Bacteria (BPCP's). Some bacteria of the genera Azospirillum, Pseudomonas, Bacillus, Azotobacter act directly through the mechanisms of mineralization and solubilization, synthesis of growth regulators and, mainly, BNF, directly assisting in plant growth and improving the acquisition of nutrients by the plant. In addition to the production of volatile organic compounds (VOCs) that have antifungal activity. In an indirect way, microorganisms act through secondary products in the phytopathogenic control and resistance of plants to abiotic stress conditions, through the production of the enzyme ACC deaminase. The combination of beneficial microorganisms and their different mechanisms of action is applied through the technology known as co-inoculation, which involves the synergism of the combination of different genera of microorganisms, seeking ease of application with the use of a single inoculant and enhancing better plant performance and economy in soybean and common bean crops. Co-inoculation with common bean represents a significant advance, especially co-inoculation with R. tropici and A. brasilense, which promotes a reduction in production costs and increased productivity. However, in the production process of inoculants on an industrial scale, the choice of the vehicle and consortium of microorganisms, the quality control parameters and techniques used for quality assurance, are essential to ensure the maintenance of the quality and number of viable cells and, free of contaminants to ensure the success of the inoculant application and its efficiency in the field. Regarding the 2nd theme, in recent years, research on the bean microbiome has aroused significant interest due to its potential for plant nutrition, protection against pathogens and adaptation to changing environmental conditions. However, understanding and assembling the plant microbiome is a complex process, due to the relationship between plants and microorganisms and their interactions with the environment being complex. Understanding the bean microbiome offers some benefits, both in plant development, protection and resistance to environmental stresses, and in the development of new agricultural practices, through the application of beneficial microorganism communities to increase productivity and sustainability in the bean production system. In addition, the significant economic effects of fungal plant diseases result from declining agricultural production and quality. It is feasible to manage fungal diseases of plants through the various actions of microorganisms active in biocontrol. The biological management of plant diseases is still advancing, mainly due to its inconsistent efficacy under various climatic circumstances. Numerous biocontrol-active bacteria create compounds that can inhibit the development and activity of pathogens. This makes it necessary to use methods to understand the responses of plants to inoculation of protective bacteria, such as genomic and transcriptomic analysis, proteomics, microscopy, and studies of mutants and reverse genetics. Therefore, these responses are essential to increase the development and efficiency of intercropped inoculants in common bean.