Banca de QUALIFICAÇÃO: ARTHUR VALBON RODRIGUES

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : ARTHUR VALBON RODRIGUES
DATA : 13/12/2017
HORA: 13:00
LOCAL: UFRRJ PPGQ
TÍTULO:

SYNTHESIS AND EVALUATIONS OF THE ANTIBACTERIAL ACTIVITY OF NEW 2-IMINO-ALQUIL-1,3-TIAZINES AND 2-IMINO-ARIL-1,3-TIAZINES 

PALAVRAS-CHAVES:

Antibiotic, Imine, Tiazine, Molecular Hybridization, Pathogenic Bacteria

PÁGINAS: 60
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
RESUMO:

The infections caused by pathogenic bacteria are problems that affect the world health hundreds of years ago. Thereby, at the beginning of the century were discovered the first medications efficient in combat this diseases, the antibiotics. However, along with the discovery came to bacterial resistance, responsible by bacterial adaptation to the medication, that can inactive or decrease it efficiency. Actually, seventy percent of the bacteria already show resistance to at least one antibiotic used in the infections treatment. Thus, the development of new substances to combat of pathogenic bacteria is essential to maintenance of the world health. Thus, the present project of research aims that the development and evaluation of one chemical class resulting from the molecular hybridization of 1,3-tiazines and imines, due  this class already have records in the literature for this purpose. In this project will be sintered two series (A and B), with fourteen compounds of the 2-imino-alquil-1,3-tazines class and fourteen compounds of the 2-imino-aril-1,3-tiazines, both unpublished in the literature. After synthetized, antibacterial activity will be tested against the bacteria: Bacillus subtilis (INCQS 00001), Escherichia coli (CCBH 3860), Enterococcus faecalis (CCBH 5069), Klebsiella pneumoniae (INCQS 000532), Pseudomonas aeruginosa (INCQS 00099), Staphylococcus aureus (INCQS 00015), Acinetobacter baumannii (CCBH 24360) Bacillus cereus (INCQS 00304), Klebsiella pneumoniae (ATCC 70063).

MEMBROS DA BANCA:
Interno - 3278519 - DARI CESARIN SOBRINHO
Externo ao Programa - 1815763 - IRENE DA SILVA COELHO
Presidente - 1058758 - MARCO EDILSON FREIRE DE LIMA