Banca de QUALIFICAÇÃO: ELAINE RODRIGUES MIRANDA NERY DA SILVA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ELAINE RODRIGUES MIRANDA NERY DA SILVA
DATE: 27/06/2024
TIME: 13:00
LOCAL: sala 50 do prédio de química
TITLE:

Effects of exposure to Bisphenol S and microplastic eluents on the
energetic metabolism of zebra fish

KEY WORDS:

fish, waste, pollution, contamination, metabolism, environment, health

PAGES: 17
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

Microplastics (the exposure of animals to bisfenol  and microplastics) have raised concerns regarding their adverse effects on human metabolism and aquatic organisms. Recent studies have shown that despite being frequently used as a substitute for bisphenol A (BPA) in the production of plastic tableware for food and beverage storage, Bisphenol S (BPS) has endocrine-disrupting properties, affects lipid homeostasis, and causes lipidogenic effects. When inappropriately discarded, these plastics accumulate on the surface of the soil or oceans and degrade over time, forming smaller fragments owing to exposure to sunlight, temperature variations, and friction. Such fragments are known as plastic microparticles (MPs) when they reach sizes between 0.1 and 5000 microns. MPs) are microscopic plastic particles that are ubiquitous in aquatic environments and can bind to other hydrophobic substances or chemicals that interact with the biota. However, the physiological effects of substances produced by MP degradation in animal organisms are not always observed. There is evidence that synthetic bisphenol compounds exposed to fish, such as zebrafish, can generate significant metabolic changes, such as endocrine disruption, altered gene expression related to energy metabolism, impairment of bioenergetic pathways, and induction of oxidative stress. The experimental results showed an increase in lipid levels in the plasma and liver of zebrafish exposed to Bisphenols A and S, providing an obesogenic effect. However, more studies are needed to fully understand the mechanisms underlying the molecular and long-term consequences of exposure to BPS and MEPs, especially regarding the metabolic and energetic health of zebrafish. The goal of this study was to verify the effects of Bisphenol S and aqueous extracts from samples of worn microplastics removed from the beach of Bahia de Sepetiba (RJ, Rio de Janeiro) on the metabolic profile and energy metabolism of zebrafish (Danio rerio) reared in the laboratory. Understanding chemical effects is crucial for formulating appropriate environmental policies and mitigation strategies to protect both the aquatic environment and human health.

COMMITTEE MEMBERS:
Interno - 1844240 - CRISTIANO JORGE RIGER
Interno - 1144471 - IDIO ALVES DE SOUSA FILHO
Interna - 1177598 - ROSANE NORA CASTRO
Externa ao Programa - 2860277 - ISABELE DA COSTA ANGELO - UFRRJExterna ao Programa - 2142679 - LEILANE MARIA BARCELLOS NEPOMUCENO - UFRRJ