Banca de DEFESA: HENRIQUETA TALITA GUIMARÃES BARBOZA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : HENRIQUETA TALITA GUIMARÃES BARBOZA
DATA : 26/04/2018
HORA: 09:00
LOCAL: UFRRJ-ICE-PPGQ-Sala 50
TÍTULO:

Synthesis, characterization and study of the fungicidal and carginogenic activity of new dialkylphosphorylacylhydrazones

PALAVRAS-CHAVES:

Organophosphorus, hydrazones, acethylcolinesterase, post-harvest fungusand melanoma

PÁGINAS: 418
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Síntese Orgânica
RESUMO:

The present work refers to the synthesis of novel dialkylphosphorylacylhydrazones that occurs in 3 reaction steps: the first step consisted in the synthesis of different dialkyl acetate phosphonoacetates obtained by the reaction of the ethylbromoacetate with the trialkyl phosphite of interest. The second step was the synthesis of acetic diethoxyphosphonylhydrazides which occured by reaction between dialkyl phosphonoacetates synthesized and hydrazine. The third and final ones occured by the condensation of acetic diethoxyphosphonylhydrazides with different heterocyclic aldehydes. The obtained compounds were characterized by 1-H and 13-C and 31-P NMR, infrared (IR) and mass spectroscopy (MS). In total, 17 unpublished compounds, namely one to 17, respectively, were obtained with diastereoisomeric mixture of preferential conformation E. The fungicidal activity of each synthesized molecule was tested against plant pathogens fungi responsible for postharvest diseases of economic importance such as Pilidium sp., Alternaria sp., Penicilium sp. and Colletotrichum gloeosporioides, however, they did not present fungicidal activity in the evaluated fungi. The compounds were further tested on melanoma cells, for the purpose of verify whether they have any activity in tumor growth of melanoma cells, but only compounds 2 and 10 showed some biological activity, although relatively low.After synthesis and purification of the synthesized compounds, they are checked against the acetylcholinesterase enzyme activity. The AChE enzyme inhibition assay has shown that compound 2 does not inhibit the enzyme along with compounds 3, 7, 8 and 16 while compound 13 in addition to compound 9 strongly inhibits AChE and even more inhibitors than the standard used, the Propoxur.

MEMBROS DA BANCA:
Presidente - 980939 - JOAO BATISTA NEVES DA COSTA
Interno - 2181682 - MARCIA CRISTINA CAMPOS DE OLIVEIRA
Interno - 1058758 - MARCO EDILSON FREIRE DE LIMA
Externo ao Programa - 1219728 - REGINA CELI CAVESTRE CONEGLIAN
Externo à Instituição - ANTONIO GOMES SOARES - EMBRAPA
Externo à Instituição - MARCOS COSTA DE SOUZA - UFF
Externo à Instituição - OTNIEL FREITAS SILVA - EMBRAPA