Banca de QUALIFICAÇÃO: TAMIRES DE ALMEIDA CRUZ

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : TAMIRES DE ALMEIDA CRUZ
DATE: 07/05/2025
TIME: 10:00
LOCAL: Salas 49 ou 50 do Instituto de Química na UFRRJ
TITLE:

Manipulation of the Endocannabinoid System and its effects on ADHD-related behaviors and Dopaminergic and Norepinephrinergic Neurotransmission in an animal model

KEY WORDS:

ADHD, Dopamine, Norepinephrine, Endocannabinoid System.

PAGES: 15
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Química dos Produtos Naturais
SUMMARY:

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by cognitive and behavioral dysfunctions, such as attention deficit, impulsivity, and hyperactivity. The neurobiological underpinnings involved in ADHD are not yet fully elucidated. Dopamine, which controls many vital physiological functions and complex behaviors, and norepinephrine, which is involved in attention processes, are neurotransmitters that appear to play an important role in several neuropsychiatric disorders, such as schizophrenia and ADHD. Evidence indicates that alterations in the dopaminergic and norepinephrinergic systems in the prefrontal cortex contribute significantly to its pathophysiology. Dopamine and norepinephrine transporters play central roles in the homeostasis of these neurotransmitters and in the modulation of executive functions. The endocannabinoid system (ECS), through the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), CB1 and CB2 receptors, and enzymes involved in their synthesis and degradation, regulates neurobiological processes such as cognition, emotion, and memory. Studies indicate that the ECS functionally interacts with the dopaminergic and norepinephrinergic systems, suggesting a relevant modulatory role in the neurobiology of ADHD. Animal models such as DAT-KO mice, which have a deletion of the DAT gene, have been widely used to investigate the consequences of dopaminergic hyperfunction, demonstrating phenotypes compatible with ADHD symptoms. Thus, the analysis of the interaction between the ECS and the dopaminergic and norepinephrinergic systems may contribute to the advancement of the pathophysiological understanding of ADHD and open new therapeutic possibilities.

COMMITTEE MEMBERS:
Presidente - 3145590 - DANIELA COSENTINO GOMES
Externo ao Programa - 1807841 - ANDRE LUIZ GOMES VIEIRA - UFRRJExterno ao Programa - 1674073 - BRUNO GUIMARAES MARINHO - UFRRJExterno ao Programa - 2582213 - MARCO ANDRE ALVES DE SOUZA - UFRRJExterna ao Programa - 1700427 - YARA PELUSO CID - UFRRJ