Banca de DEFESA: CARLA CRISTINA DA SILVA
Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.DISCENTE : CARLA CRISTINA DA SILVA
DATA : 15/08/2018
HORA: 10:00
LOCAL: Instituto de Química - Sala 50
TÍTULO:
Synthesis and antibacterial activity of aminoderivados of the 1.4-naphthoquinone
PALAVRAS-CHAVES:
naphthoquinones, antibacterial activity, serum human albumin
PÁGINAS: 95
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
RESUMO:
Bacteria are unicellular beings that can be found alone or in colonies. In the 19th century, scientists began to associate some diseases with certain species of bacteria. Researchers have since sought compounds capable of acting on these species of bacteria and minimizing the effects of diseases, some of which are considered serious. Several classes of compounds have been discovered throughout the 20th century capable of inhibiting the growth or even causing the death of pathogenic bacteria. However, the large capacity of these mutated bacteria led to the emergence of strains resistant to these substances. Thus, the development of new compounds with antibacterial potential is necessary. In this work 11 compounds were synthesized from the reaction of 1,4-naphthoquinone and 11 different amines. The compounds obtained were characterized by infrared and 1H and 13C NMR spectroscopy. Six compounds were selected for biological assay against 9 strains of different bacteria, the NQA, NQC and NQG compounds being active against several different bacteria, in concentrations that varied between 31.2 and 250 mg / mL. For the compounds that showed better activity, the interaction with serum human albumin, a protein present in large numbers in the higher mammals and responsible for the transport of biologically active molecules, was tested.
MEMBROS DA BANCA:
Presidente - 387189 - AUREA ECHEVARRIA AZNAR NEVES LIMA
Externo à Instituição - CLEBER BONFIM BARRETO JUNIOR - IFRJ
Interno - 2181682 - MARCIA CRISTINA CAMPOS DE OLIVEIRA
Externo à Instituição - MARIA RAQUEL GARCIA VEJA - UENF
Interno - 1177598 - ROSANE NORA CASTRO