Banca de QUALIFICAÇÃO: PAULA DO NASCIMENTO GOULART

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : PAULA DO NASCIMENTO GOULART
DATA : 20/02/2020
HORA: 09:00
LOCAL: PQ sala 50
TÍTULO:

SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW [1,2,3] -TRIAZOLES DESIGNED AS NS5B ENZYME  INHIBITORS FOR THE TREATMENT OF HEPATITIS C


PALAVRAS-CHAVES:

hepatitis C, NS5B polymerase, Sofosbuvir, triazoles.


PÁGINAS: 20
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Síntese Orgânica
RESUMO:
Hepatitis C is an infectious disease discovered in 1989, caused by viruses that mainly affect the liver. It is estimated that 3% of the world population is infected with the hepatitis C virus (HCV), which manifests asymptomatically in most of the cases, being the main cause of liver cirrhosis, thus making HCV a health problem worldwide, for which there is no vaccine. Therefore, it is understood the importance of carrying out an appropriate treatment, with the highest possible adherence rate to avoid future complications of this infection. Before 2011, treatment was carried out with a combination of peginterferon and ribavirin, which had a cure rate of only 50% and had greater adverse effects. Currently, the infection can be treated with direct-acting antivirals, such as sofosbuvir, whose cure rate is 90%. However, access to new drugs has high costs, in addition to presenting a high risk of resistance, problems in absorption and other undesirable effects. Due to biological diversity, triazoles are good research targets for the treatment of diseases caused by RNA viruses. Thus, this project proposes the synthetic planning and biological evaluations of new triazole nucleoside inhibitors, which will be planned as bioisters of SOFOSBUVIR, which has antiviral activity, acting as an inhibitor of the NS5B polymerase enzyme. Obtaining the series of compounds is based on reactions of organic synthesis such as cyclocondensations, diazotation and reactions of "click chemistry". The compounds obtained will be purified and then characterized by spectroscopic techniques (1H and 13C NMR, IV) and EM. In addition to the investigation of the bioactivity profile in in vitro models of NS5B inhibition and by theoretical methods of molecular modeling of the interaction profile of the series of compounds synthesized with NS5B, as well as the activity structure correlation. It is expected, with this methodological strategy, to reach new molecular models that present activity against NS5B and that can be efficient alternatives to SOFOSBUVIR.

MEMBROS DA BANCA:
Presidente - 980939 - JOAO BATISTA NEVES DA COSTA
Interno - 1221906 - LUCIANO RAMOS SUZART
Externo ao Programa - 386960 - WELLINGTON DA SILVA CORTES
Notícia cadastrada em: 17/02/2020 06:46
SIGAA | Coordenadoria de Tecnologia da Informação e Comunicação - COTIC/UFRRJ - (21) 2681-4638 | Copyright © 2006-2026 - UFRN - sig-node1.ufrrj.br.producao1i1