Banca de QUALIFICAÇÃO: SABRINA NEVES SANTOS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE : SABRINA NEVES SANTOS
DATA : 28/12/2018
HORA: 10:00
LOCAL: Instituto de Química
TÍTULO:

Biological planning, synthesis and evaluation of novel hybrid coumarins inhibitors of transciptase 
revins and enzyme integrated for the treatment of HIV-1

PALAVRAS-CHAVES:

HIV, Integrase, Reverse Transcriptase

PÁGINAS: 20
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
RESUMO:

AIDS (acquired immunodeficiency syndrome) is a complex of symptoms and

diseases that manifest themselves after infection of the human body with HIV (

immunodeficiency). HIV is a retrovirus of the Retroviridae family, as in

other retroviruses, the HIV genome is composed of two single strands of positive RNA

and identical with each other that cause in the body a chronic immune dysfunction and

progressive decline due to the decline in levels of CD4 + T lymphocytes that are defense cells

of the human organism. There are currently two types of HIV identified called

of HIV-1 and HIV-2. HIV is an infection that represents one of the biggest problems

public health, due to its pandemic and seriousness. By 2017, there were in the world

36.9 million adults living with HIV. Despite the growth of the

world, the development of antiretrovirals (ARVs) has changed the lives of individuals

living with HIV / AIDS. Morbidity and mortality declined between 60 and 80%,

mainly due to the availability of different classes of ARV drugs and the use in

combination of three or more of them. However, the development of resistance to

continues to be one of the most serious obstacles to halting the spread of

of HIV during highly active antiretroviral therapy and this has been of great

throughout the world. In this way, considering the deficiencies of the therapies

currently available, in terms of side effects and resistance to the virus, there are

need to discover new molecules that are effective against viruses

resistant and also have fewer side effects. Thus, this project has

as an objective the planning of coumarin hybrid compounds planned

as inhibitors of the reverse transcriptase and integrase enzymes. The bioactivity profile

of the synthesized compounds will be carried out in in vitro models of inhibition of enzymes

reverse transcriptase and integrase.

 

MEMBROS DA BANCA:
Presidente - 1221906 - LUCIANO RAMOS SUZART
Interno - 1979542 - RENATA BARBOSA LACERDA
Externo à Instituição - MARINA AMARAL ALVES - UFRJ