Banca de DEFESA: VITORIA DE SOUZA FERNANDES DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : VITORIA DE SOUZA FERNANDES DA SILVA
DATE: 07/10/2021
TIME: 10:00
LOCAL: Plataforma virtual
TITLE:

Design, synthesis and evaluation of the potential antiparasitic activity of dihydropyrimidinones and quinazolines obtained from Multicomponent Reactions

KEY WORDS:

Malaria, Multicomponent Reaction, Biginelli, Dihydropyrimidinone, Quinazolinone.

PAGES: 117
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

Malaria is an infectious and potentially fatal disease caused by protozoa of the
Plasmodium genus, its main vector of transmission is the bite of the female Anopheles
mosquito. Despite being considered one of the diseases with the greatest impact on
morbidity and mortality in countries located in the tropical and subtropical regions of the
planet, there are still not many treatment alternatives that use effective drugs, with low
toxicity and that did not present cases of resistance. Multicomponent reactions (MCR)
are a powerful tool in the search for new drug candidates due to their display of
advantages compared to conventional linear syntheses, and for following principles of
Green Chemistry. Dihydropyrimidinones (DHPMs), products of Biginelli's MCR, are N-
heterocyclic systems that have several pharmacological properties and an easily
reproducible synthetic route, enabling the production of a library of structurally distinct
molecules that can exhibit bioactivity or be modified for this purpose. In this work,
twenty-two DHMPs and nine Quinazolinones were synthesized, five of which were new,
through the use of functionalized derivatives in Biginelli's RMC, allowing the creation of
a library of molecules with different structures and possible antimalarial activity. The
methodology used proved to be effective and simple, allowing the use of readily
commercially accessible reagents, which allowed the synthesis of different compounds
with yields ranging from 15 to 88%. Tests to verify the potential biological activity of the
products obtained are in progress.

BANKING MEMBERS:
Presidente - 1735975 - CEDRIC STEPHAN GRAEBIN
Interno - 2624418 - CLAUDIO EDUARDO RODRIGUES DOS SANTOS
Interna - 1979542 - RENATA BARBOSA LACERDA
Externo à Instituição - JONES LIMBERGER - PUC - RJ
Externa à Instituição - Roberta Katlen Fusco marra - UFRJ