Banca de DEFESA: DOUGLAS CHAVES DE ALCÂNTARA PINTO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : DOUGLAS CHAVES DE ALCÂNTARA PINTO
DATE: 25/10/2022
TIME: 09:00
LOCAL: Apresentação em ambiente virtual, via Google Meet (Link: https://meet.google.com/sbo-oyqd-pkv)
TITLE:

Desing, synthesis and biological evaluation of new quinolinic derivatives against Mycobacterium tuberculosis

KEY WORDS:

Tuberculosis, chemotherapy, DNA gyrase, molecular hybridization

PAGES: 220
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

Tuberculosis (TB) infection caused by the microorganism Mycobacterium tuberculosis, is currently one of the infectious diseases with high mortality potential, due to the emergence of strains resistant to the drugs available for treatment. The disease occurs latently, the infected individual will present the symptoms years later, being able to develop the multidrug-resistant type (TB-MDR, of the multidrug-resistant English) and the extensively resistant type (TB-XDR, of the extensively drug-resistant English) these variations of the disease represent a major challenge for public health authorities. Although the Stop-Tuberculosis plan has shown some promising results, the fact is that in the current scenario the global reduction rates for the treatment of TB-MDR / XDR are below 50%, being even lower when the spectrum of drug resistance goes beyond that of TB-XDR. The reduction in health supplies and financing from international agencies, the long treatment and the high incidence of adverse events make the task of combating tuberculosis even more difficult. After more than 40 years of neglect, more attention has recently been given to the need for new drugs to fight the disease. Several research works have been carried out recently with the objective of improving the treatment for TB-MDR / XDR. These researches seek therapeutic alternatives for the development of effective drugs. Thus, the development of new substances for the treatment of infection is of relevant interest in the scientific community. This project aims to develop and evaluate the cytotoxic potential of new quinolinic derivatives resulting / planned from the structural modification of 2-chloro-quinoline-3-carbaldehyde, giving rise to new nitrogen-containing heterocyclic compounds. Planned due to the performance of computational studies in order to discover the possible molecular interaction sites of the derivatives with the enzyme DNA gyrase, related to cell replication, obtaining information on the mechanisms of action of these new compounds.

BANKING MEMBERS:
Presidente - 1058758 - MARCO EDILSON FREIRE DE LIMA
Interna - 3145590 - DANIELA COSENTINO GOMES
Interno - 1220404 - CARLOS MAURICIO RABELLO DE SANT ANNA
Externa à Instituição - WANDA PEREIRA ALMEIDA - UNICAMP
Externo à Instituição - GUSTAVO HENRIQUE GOULART TROSSINI - USP
Externo à Instituição - FERNANDO DE CARVALHO DA SILVA - UFF
Externo à Instituição - SÉRGIO PINHEIRO - UFF