Banca de DEFESA: ATILA MENEGARDO MOFATI

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ATILA MENEGARDO MOFATI
DATE: 18/08/2023
TIME: 09:00
LOCAL: Plataforma virtual (Microsoft Teams)
TITLE:

DESIGN, SYNTHESIS AND THE ANTI-Plasmodium falciparum ACTIVITY OF HETEROCYCLIC COMPOUNDS OBTAINED FROM MULTICOMPONENT REACTIONS

PLANEJAMENTO, SÍNTESE E AVALIAÇÃO DA ATIVIDADE ANTI-Plasmodium falciparum DE HETEROCICLOS OBTIDOS A PARTIR DE REAÇÕES MULTICOMPONENTES

KEY WORDS:

Malaria, Multicomponent Reaction, Hantzsch 

PAGES: 209
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

Malaria is a potentially serious infectious disease caused by protozoa of the genus Plasmodium, which is widely distributed throughout the world. In 2021, it is estimated that there will have been about 247 million cases and 617 thousand deaths from malaria in the world. Being transmitted through the bite of mosquitoes of the genus Anopheles, malaria is more common in regions where there is a greater proliferation of these vectors, that is, in regions with a tropical and subtropical climate. The fight against malaria is made difficult due to several factors, among which: the resistance of the pathogen to the main treatments and the toxicity they have. Thus, it is necessary to search for new drugs capable of effectively combating the protozoan that causes the disease, in addition to having fewer side effects. The chromens are an class of molecules that have shown interesting biological activities, including the inhibition of protozoa. Furthermore, this class of compounds does not have high levels of toxicity, making them good candidates for the treatment of malaria. One of the ways to obtain chromenes is through multicomponent reactions that are reactions carried out in a one pot way, following the principles of green chemistry, that is, it maintains a great atomic economy, produces little waste and is safe. One of the multicomponent reactions that stands out is the Hantzsch reaction, which generates, as a product, a series of heterocycles of interest, and from a modification in the protocols it is possible to obtain an even greater diversity of compounds. From multicomponent reactions, a total of 28 different compounds were obtained, which were submitted to purity analyses, infrared spectroscopy and nuclear magnetic resonance in order to guarantee the submitted structure, later preliminary tests were carried out against the NF54 strain, sensitive to chloroquine.  

COMMITTEE MEMBERS:
Presidente - 1735975 - CEDRIC STEPHAN GRAEBIN
Interno - 2624418 - CLAUDIO EDUARDO RODRIGUES DOS SANTOS
Externa ao Programa - 1222756 - DEBORA DECOTE RICARDO DE LIMA - UFRRJExterno à Instituição - OTAVIO AUGUSTO CHAVES - UC
Externa à Instituição - Roberta Katlen Fusco marra - UFRJ