Banca de DEFESA: LUAN VALIM DOS SANTOS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LUAN VALIM DOS SANTOS
DATE: 27/11/2025
TIME: 09:00
LOCAL: Prédio de Química - Sala 50
TITLE:

Effects of morin hydrate on the development and metabolism of Aedes aegypti.

KEY WORDS:

Flavonoid, biological control, larval development, energy metabolism, vector susceptibility.

PAGES: 204
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

Aedes aegypti is the primary vector of arboviruses with major public health impact, such as dengue, Zika, chikungunya, and Mayaro fever, being capable of adapting to diverse environments and developing resistance to synthetic insecticides. In this context, natural compounds such as flavonoids emerge as promising alternatives for integrated vector management. Morin hydrate, a plant-derived flavonol, has been investigated for its pharmacological properties, but its effects on insect vectors remain poorly understood. The aim of this study was to comprehensively evaluate the effects of morin hydrate on the energy metabolism and biological parameters of A. aegypti, with emphasis on survival, development, fertility, and vector competence. Laboratory assays were conducted using larvae exposed to the compound at different concentrations and under variable nutritional conditions. Growth, survival, energy reserves, biochemical and metabolomic profiles were assessed, in addition to infection assays with Mayaro virus and complementary toxicity analyses in non-target organisms. The results showed that morin hydrate induces dose-dependent larval mortality, delays development, and reduces female fertility, even when exposure occurs only at juvenile stages. Significant depletion of lipids, carbohydrates, and proteins was observed, associated with alterations in metabolic pathways and the induction of oxidative stress, establishing a physiological state similar to starvation. This energy imbalance persisted into adulthood, impairing reproduction and decreasing vector competence for Mayaro virus. Moreover, toxicity tests in mice revealed no relevant adverse effects, supporting the selective and environmentally safe potential of the compound. Collectively, the findings demonstrate that morin hydrate acts as a multifunctional metabolic modulator, simultaneously impairing survival, metabolism, development, and reproduction of A. aegypti, representing a promising alternative for the development of sustainable and selective vector control strategies.

COMMITTEE MEMBERS:
Presidente - 1555317 - EMERSON GUEDES PONTES
Interna - 1979542 - RENATA BARBOSA LACERDA
Interno - 1705075 - DOUGLAS SIQUEIRA DE ALMEIDA CHAVES
Interno - 1058758 - MARCO EDILSON FREIRE DE LIMA
Externa ao Programa - 1792175 - PATRICIA FAMPA NEGREIROS LIMA - UFRRJExterno à Instituição - ADEMIR DE JESUS MARTINS JUNIOR
Externa à Instituição - KATIA CALP GONDIM
Externo à Instituição - JORGE LUIZ DA CUNHA MORAES - UFRJ