Banca de DEFESA: LIN MACHADO DE LIMA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : LIN MACHADO DE LIMA
DATA : 01/07/2019
HORA: 13:00
LOCAL: sala 50, prédio PQ
TÍTULO:

Study of the inhibition of monoamine oxidase by new synthetic compounds derived from coumarin.

PALAVRAS-CHAVES:

Monoamine oxidase; Coumarin; Enzymes Inhibitors

PÁGINAS: 50
GRANDE ÁREA: Ciências Biológicas
ÁREA: Bioquímica
SUBÁREA: Enzimologia
RESUMO:

Monoamine oxidase [EC 1.4.3.4 (MAO)] is an enzyme located in the outer membrane of the mitochondria, which uses flavin adenine dinucleotide (FAD) as a cofactor to catalyze the oxidant conversion of an amine in its corresponding aldehyde, also producing ammonia and hydrogen peroxide. MAO activity regulates the levels of biogenic amines present in tissues, especially in the brain. MAO exists as two proteins: MAO-A and MAO-B. These isoforms were defined primarily by substrate affinities and inhibitor sensitivity. Accordingly, MAO-A oxidizes, preferably, serotonin, melatonin, noradrenaline and adrenaline. MAO-B preferably oxidizes phenylethylamine, an alkaloid from the metabolism of phenylalanine. The ingestion of phenylethylamine promotes the release of dopamine that acts in the brain stimulating euphoria. Concerning the inhibitors, MAO-A is preferentially inhibited by clorgiline. MAO-B is inhibited by deprenyl and pargyline. These inhibitorscan be used in the treatment of degenerative brain diseases.Since studies have shown that molecules derived from coumarins achieved excellent results as inhibitors of these enzymes, several new drugs derived from coumarin have been synthesized, which a few are very promising in the treatment of Alzheimer's and Parkinson's diseases. This study aimed to promote in vitro inhibition tests of MAO with new substances derived from coumarin.

MEMBROS DA BANCA:
Presidente - 1681790 - CRISTIANE MARTINS CARDOSO DE SALLES
Externo ao Programa - 1807841 - ANDRE LUIZ GOMES VIEIRA
Externo ao Programa - 1809123 - ANDRE MARQUES DOS SANTOS
Externo à Instituição - DANIELE CORRÊA FERNANDES - UERJ
Externo à Instituição - JAYME DA CUNHA BASTOS NETO - UERJ