Banca de QUALIFICAÇÃO: JOANA DARC DA SILVA TRINDADE
Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.DISCENTE : JOANA DARC DA SILVA TRINDADE
DATA : 27/06/2018
HORA: 13:00
LOCAL: Sala 50 - Pavilhão de Química
TÍTULO:
Design, synthesis, and assessment of antifungic activity of novel 5-alkyl-1,3-4-oxadiazoles and 1,2,4-triazoles.
PALAVRAS-CHAVES:
Key words: Opportunistic fungi, Candida albicans, antifungal heterocycles, CYP51.
PÁGINAS: 20
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Orgânica
ESPECIALIDADE: Síntese Orgânica
RESUMO:
Candida albicans is an opportunistic fungus commensal and colonizer of the skin and mucous membranes of man. It is also the most common fungus in humans, especially in immunosuppressed patients, such as those with cancer, or in a hospital environment, for example. The life stage of this fungus involves regulation and adaptation to the microenvironment of the host. It seems that the cellular biology of this microorganism has evolved to allow the establishment of different types of relation with the human host. There are several studies to elucidate the mechanisms that allow C. albicans to occupy different body sites, so that it is not eliminated by the common activities of the human immune system. It is estimated a worldwide scenario of deaths of between 250 and 450,000 each year caused by the fungus, with about 100 million episodes of recurrent vaginitis, and in up to 20% of infected women cases may be asymptomatic and considered as recurrent infection . Recurrence of vulvo-vaginal candidiasis can cause uncontrolled diabetes mellitus and immunosuppression. Treatment is only by administration of imidazoles. Thus, the development of new substances for the treatment of infection is of interest to the health of humans around the world. In this project, the development and evaluation of chemical classes resulting from structural modifications in two classes of nitrogenous heterocycles is discussed, since the literature presents many works involving studies of the antifungal activity of this family of compounds. Additionally, it is intended to do a docking study to evaluate possible interaction of the active site of the 14-α-demethylase of C. albicans, enzyme responsible for ergosterol biosynthesis in the fungus, with the planned substances. This study will provide information on the possible mechanism of the antifungal action of the new synthesized derivatives.
MEMBROS DA BANCA:
Interno - 1681790 - CRISTIANE MARTINS CARDOSO DE SALLES
Externo ao Programa - 387084 - GLORIA MARIA DIREITO
Externo ao Programa - 1545840 - LUCIA HELENA PINTO DA SILVA
Interno - 1221906 - LUCIANO RAMOS SUZART
Interno - 1177598 - ROSANE NORA CASTRO