Banca de QUALIFICAÇÃO: HENRIQUE JEFFERSON DE ARRUDA
Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.STUDENT : HENRIQUE JEFFERSON DE ARRUDA
DATE: 21/08/2020
TIME: 13:00
LOCAL: Apresentação remota por vídeo conferência
TITLE:
NOVEL VANADIUM COMPLEXES CONTAINING QUINOLINONES AS PROTOTYPES IN OBTAINING INSULIN-MIMETICS - A USE OF BIOISOSTERISM
KEY WORDS:
Diabetes Mellitus, vanadium complex, insulin-mimetic
PAGES: 20
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:
Diabetes mellitus (DM) is a heterogeneous metabolic disease, characterized by a relative, or even absolute, lack of insulin that is cut off by the β cells of the increase, resulting in a malabsorption of the fatty energy metabolism, and partly malabsorption. glucose from peripheral tissues, such as skeletal muscle and adipose tissue. In 2012, it was found that in the most advanced countries, where food is plentiful, above 10% of the population, it becomes diabetic throughout its life. Since the discovery that vanadium is capable of performing an insulin-mimetic action and, moreover, that it has antitumor activity, has increased the motivation to study its complexes with different types of ligands. Vanadium can present several oxidation states, from -3 to +5, or which gives great versatility within chemical bioinorganics. This diversity of oxidation states that vanadium can assume allows the formation of V-O, such as V-S and V-N, which are relatively stable. Several in vitro and in vivo studies have demonstrated that vanadium compounds can be used as mimics of insulin action, thus promoting, or transporting and oxidizing glucose in adipocytes, stimulating the glycogen statistics in the liver and diaphragm, inhibiting the glycogenolysis in hepatocytes, in addition to influencing the translation of GLUT4 transport to a plasma membrane of muscle cells, thus reducing glucose uptake. Several vanadium compounds chelated with organic molecules are more potent than free ones in relation to insulin-mimetic effects in vitro and in vivo. These complexes have a property to increase insulin-mimetic efficiency with a reduction in the levels of toxicity of vanadilla (VO), but they know little about the redox properties used in the functions of physiological activity. Therefore, this project approved as analyzes, is characterized by spectroscopic and biological tests of new vanadium compounds, which are quinolinics that were designed as insulin-mimetic prototypes used in maltol and its central vanadium component (BMOV). The production of the series of compounds is based on classic organic variations, as well as coordination with vanadium. The selected compounds will be purified and then characterized by spectroscopic techniques (1H and 13C NMR, IR) and EM. Subsequently, in vitro and in vivo tests for biological evaluation of these compounds will be performed.
BANKING MEMBERS:
Presidente - 1844240 - CRISTIANO JORGE RIGER
Externo ao Programa - 1879496 - GUSTAVO BEZERRA DA SILVA
Externo à Instituição - MAURÍCIO LANZNASTER - UFF