Banca de QUALIFICAÇÃO: AFONSO SANTINE MAGALHÃES MESQUITA VELEZ

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : AFONSO SANTINE MAGALHÃES MESQUITA VELEZ
DATE: 13/12/2023
TIME: 13:00
LOCAL: Sala 50, Pavilhão de Química-UFRRJ
TITLE:

DESIGN, SYNTHESIS AND LEISHMANICIDAL EVALUATION OF NEW DIMERIC LINALOOL DERIVATIVES AGAINST Leishmania amazonensis

KEY WORDS:

chemotherapy; dimerization of pharmacophore, monoterpenes, essential oils.

PAGES: 20
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

Leishmaniasis represent a group of diseases that are considered one of the main neglected tropical diseases, caused by a protozoan of the genus Leishmania. The main vector of this infection is the female sandfly (Lutzomyia longipalpis), which transmits the parasite when taking a blood meal from the host. Millions of individuals around the world live with the different clinical manifestations of this disease. In addition, people living in situations of economic vulnerability, in direct contact with their transmission vector, are constantly subject to infection. Traditional therapy for this disease relies on drugs with high toxicity as well unsatisfactory cure rate for the infected patients. Therefore, the search for new anti-Leishmania treatments is a constant demand, and the class of natural products calways proves to be a great alternative, given its relevant contribution to the development of drugs used in the most diverse therapies with high success. The natural product chosen to carry out structural modifications in this work is linalool, a monoterpene found in essential oils from several plant species, which has shown very promising antiparasitic activity, especially against some species of Leishmania. Therefore, it is understood that by increasing the availability of the active structural unit of the natural product linalool through the strategy of dimerization of its structure in the same molecule, we will thus increase its bioavailability in the biological environment, and enhancing its activity. The synthesis of these regioisomeric dimers of linalool will be carried out using the Heck reaction methodology, catalyzed by palladium; The leishmanicidal potential of these compounds will be evaluated against the promastigotes and amastigotes forms of L. amazonensis.

COMMITTEE MEMBERS:
Interna - 3145590 - DANIELA COSENTINO GOMES
Interno - 2582213 - MARCO ANDRE ALVES DE SOUZA
Interna - 1177598 - ROSANE NORA CASTRO
Externa ao Programa - 1335855 - DANIELLE DE OLIVEIRA NASCIMENTO - UFRRJExterna ao Programa - 1545840 - LUCIA HELENA PINTO DA SILVA - UFRRJ