Banca de QUALIFICAÇÃO: IGOR RESENDES BARBOSA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : IGOR RESENDES BARBOSA
DATE: 21/12/2023
TIME: 08:00
LOCAL: virtual
TITLE:

PLANNING, OBTAINING AND BIOLOGICAL EVALUATION OF NEW PIRIMIDONE-N-ACYL-HYDRAZONES HYBRIDS WITH POTENTIAL ACTIVITY AGAINST CHIKUNGUNYA VIRUS

KEY WORDS:

N-acylhydrazones
Isatina
Antiviral activity
CHIKUNGUNYA

PAGES: 26
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SPECIALTY: Síntese Orgânica
SUMMARY:

Chikungunya is a viral disease transmitted to humans by the bite of mosquitoes of the genus Aedes. Although the disease remained restricted to a few Asian and African territories for many years, from the early 2000s it spread to new geographic regions, putting an even greater number of individuals at risk. The main symptoms of this infection include fever, rashes and joint pain, which is often chronic and debilitating. In the Americas, the number of cases and deaths associated with Chikungunya virus infection have increased over the years, occurring mainly in Brazil and Paraguay. Recently, the FDA approved a single-dose vaccine for use in people 18 years of age and older. This vaccine is still undergoing clinical studies in Brazil, which should be completed in early 2024. Despite the encouraging results of this new vaccine, it is possible that mutant strains capable of evading the immune response, totally or partially, will emerge in the future. Therefore, it is necessary to develop drugs that are active against the virus to be added to the arsenal of measures against the disease. In this sense, the non-structural protein 3 (nsP3) of the Chikungunya virus has been considered an attractive biological target, as it has been shown to be essential for viral replication and virulence in several studies. Molecular fragments containing 2-pyrimidone-4-carboxylic acid as a common structural unit were previously identified in the literature as ligands and potential inhibitors of Chikungunya virus nsP3. Thus, this Project presents the rational planning for the synthesis of three unprecedented series of compounds based on the pyrimidone ring as potential anti-Chikungunya agents. The planned compounds have an N-acylhydrazone in their structure, a group previously identified in compounds with various biological activities, including antiviral. After obtaining them, the cytotoxicity of the compounds will be evaluated in Vero cells, and the antiviral activity will be evaluated in Vero cells infected by the Chikungunya virus. Finally, the experimental results will be correlated with Molecular Anchoring studies between these compounds and the macro domain of the nsP3 protein.

COMMITTEE MEMBERS:
Presidente - 2624418 - CLAUDIO EDUARDO RODRIGUES DOS SANTOS
Externo à Instituição - LEONARDO DOS SANTOS CORREIA AMORIM
Externa à Instituição - ROBERTA KATLEN FUSCO MARRA - UFRJ