Banca de DEFESA: DIANA DO AMARAL MENDONCA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : DIANA DO AMARAL MENDONCA
DATE: 23/08/2023
TIME: 14:00
LOCAL: meet.google.com/ovf-wmtu-gsz
TITLE:

Respiratory abnormalities in dogs with spontaneous hyperadrenocorticism

KEY WORDS:

cortisol, adrenal, cough, dyspnea.

PAGES: 36
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Spontaneous hypercortisolism is an endocrine disorder characterized by excessive production of cortisol by the adrenal cortex. Cortisol excess can cause dysfunction in different organ systems such as the respiratory system, and several mechanisms are involved in the clinical manifestations of hypercortisolism associated with the respiratory system. However, respiratory alterations, although common, are little studied in these cases. High serum glucocorticoid levels promote: i) respiratory muscle weakness; ii) accumulation of chest and abdominal fat; iii) hepatomegaly; iv) occurrence of dystrophic mineralization in different segments of the respiratory system and; vi) pulmonary fibrosis. Furthermore, it may predispose to pulmonary thromboembolism due to the increase in clotting factors. Clinical manifestations such as cough, dyspnea, cyanosis and exercise intolerance are commonly observed in dogs with spontaneous hypercortisolism. The diagnosis can be made by the low-dose dexamethasone suppression test or the adrenocorticotropic hormone (ACTH) stimulation test. The diagnosis of pulmonary alterations can be evidenced through chest radiography or chest computed tomography. Aiming to determine the most frequent pulmonary alterations in dogs with hypercortisolism and their clinical consequences, 21 dogs with hypercortisolism were submitted to evaluation of history and clinical signs, respiratory physical examination and chest X-ray. Statistical analysis was performed to verify frequency, risk analysis and normality. The radiographs were taken using digital development and parameters such as diameter of the main bronchi, pulmonary patterns, size of the pulmonary trunk and pulmonary arteries were analyzed by a certified radiologist. The most frequent clinical respiratory signs were snoring (61.9%), coughing (57.1%) and tiredness (52.4%). Two tutors reported the presence of dyspnea and one of cyanosis. In the physical examination, only one animal did not present alterations, while the highest frequency of alteration observed was alteration in pulmonary auscultation (95.2%). The body condition score was evaluated as altered in 95% of the animals and there was a correlation between body score and cyanosis and presence of alteration in pulmonary auscultation, both presenting the same level of significance and risk (p=0.02950; OR=0.000). There was also a moderate correlation (r=0.571) between weight and respiratory rate. Radiographic changes were seen in 47.5% of the animals with a higher frequency of bronchial pattern (70%). The assessment of the caudal lobar pulmonary artery was performed separately, and it was altered in 71.4% of the animals. A Spearman correlation test was performed, which showed a moderate correlation (r=0.571) between weight and respiratory rate. In the present study, it was possible to observe that dogs with excess cortisol showed respiratory and radiographic alterations. The high body score in patients with hypercortisolism was significant for the exacerbation of clinical signs of cyanosis and tachypnea. Radiographic changes in dogs with hypercortisolism were frequent, but other studies with advanced imaging techniques are needed to confirm these changes related to hypercortisolism.

COMMITTEE MEMBERS:
Presidente - 1151827 - BRUNO RICARDO SOARES ALBERIGI DA SILVA
Interno - 4563410 - JULIO ISRAEL FERNANDES
Externo ao Programa - 1120060 - ALEXANDRE JOSE RODRIGUES BENDAS - UFRRJExterno à Instituição - LEONARDO LARA E LANNA - UFJF
Externo à Instituição - FLAVYA MENDES DE ALMEIDA - UFF