Banca de QUALIFICAÇÃO: BRUNO RICARDO SOARES ALBERIGI DA SILVA
Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.DISCENTE : BRUNO RICARDO SOARES ALBERIGI DA SILVA
DATA : 30/01/2019
HORA: 09:00
LOCAL: LQEPV - Laboratório de Quimioterapia Experimental em Parasitologia Veterinária
TÍTULO:
EFFICACY OF THE ASSOCIATION OF SLOW RELEASE MOXIDECTIN (ProHeart®SR-12) + DOXYCYCLIN FOR THE TREATMENT OF Dirofilaria immitis (Leidy, 1856) NATURALLY INFECTED DOGS
PALAVRAS-CHAVES:
Keywords: Canine dirofilariosis, heartworm; diagnostic; Macrocyclic Lactone; adulticide treatment
PÁGINAS: 52
GRANDE ÁREA: Ciências Agrárias
ÁREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
ESPECIALIDADE: Clínica Veterinária
RESUMO:
Dirofilaria immitis (Leidy, 1856) Raillet & Henry 1911 is a nematode that mainly inhabits canine pulmonary arteries and right cardiac chambers. All D. immitis individuals depend upon Wolbachia bacteria to maintain their basic physiology. Dirofilaria immitis is the etiologic agent of lesions that are directly related to the duration of the infection, to the host´s immune reaction and to the host´s physical activity level. The most common clinical signs are cough and dyspnea that are often times a consequence of the disease of the lung parenchyma. The cardiopulmonary lesions can be evaluated by thoracic x-rays and by ecodopplercardiography. The adulticide treatment that can replace the recommended protocol is done by monthly administration of a Macrocyclic Lactone associated with periodical doxycyclin cycles. Since this protocol depends on owners’ compliance for at least 12 months, the frequency of treatment withdrawal is high. Therefore, aiming to evaluate the efficacy of a new treatment that does not depend on such a long time of compliance, a slow release moxidectin formulation (ProHeart SR 12®) was administered at 6 months interval in association with biannual doxycyclin (Doxifin®) cycles (moxiSR-doxy). A total of 17 D. immitis naturally infected dogs was included and monitored until they were considered to be free of the infection or for 24 months maximum. All dogs were clinically evaluated before inclusion and along all treatment. The cardiorespiratory system was meticulously evaluated every 180 days using chest x-rays and ecoddoplescardiography, besides that, the infection conditions were evaluated by microfilariae tests, microfilariae counts and by antigen detection. Out of the 17 dogs included, 15 followed the treatment with the results: i) seven were considered free of the infection at 12 months of treatment; ii) five were antigen negative for the first time at six months treatment and; iii) three were included 10 months ago and at six months they were still antigen positive. All dogs became amicrofilaremic at day 150. The majority of the cardiac and of the pulmonary lesions remained unchanged between the day of inclusion and the day dogs were considered free of infection.
MEMBROS DA BANCA:
Interno - 2318733 - DANIEL DE ALMEIDA BALTHAZAR
Externo ao Programa - 1173660 - FABIO BARBOUR SCOTT
Interno - 4563410 - JULIO ISRAEL FERNANDES
Interno - 387386 - MARTA FERNANDA ALBUQUERQUE DA SILVA
Externo ao Programa - 2929889 - THAIS RIBEIRO CORREIA AZEVEDO