Banca de DEFESA: GABRIEL CARDOSO REIS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : GABRIEL CARDOSO REIS
DATE: 23/02/2024
TIME: 13:00
LOCAL: Google meet
TITLE:

PHARMACOLOGICAL EVALUATION OF Bixa Orellana SEED EXTRACTS. L IN MICE

KEY WORDS:

Keywords: Urucum, Analgesia, Bactericide, Inflammation.

PAGES: 84
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Farmacologia e Terapêutica Animal
SUMMARY:

Pain is an extremely important sensation, as it allows the awareness that the integrity of the organism is being threatened. However, it can bring with it unpleasant consequences such as suffering, stress, damage to social and economic relationships, which is why it must be quickly and effectively controlled and treated. Therefore, the need to seek alternative measures in the development of medications for pain control becomes notable. Some of the analgesic drugs, such as opioids and non-steroidal anti-inflammatory drugs, have their origins in natural products that have been used for thousands of years throughout the development of humanity. However, currently many of these plants are marketed as if they were extremely safe for consumption, as they are a natural source. However, while scientific research is not developed, the pharmacological potential of these products is still questioned and may not exist or may even harm the individual who uses them. In Brazil, the seeds, leaves and roots of Bixa orellana (Annatto) were popularly used as an aphrodisiac medicine, as well as a remedy to treat fevers, inflammatory conditions and parasitic diseases. Many pharmacological properties have been reported for extracts from different parts of this plant, including antimicrobial. Therefore, the objective of this work was to evaluate the antinociceptive, anti-inflammatory and antibiotic activity of Bixa orellana (Annatto) seed extracts. Using Swiss mice, males weighing 20 to 25g, well-established behavioral models were performed to obtain the results. In this way, it was possible to verify that the extracts were capable of inducing antinociceptive activity in models of abdominal contortions induced by acetic acid, formalin and tail removal. The results obtained in the paw edema test indicate an antiedematogenic effect of the extracts. The extracts were able to reduce leukocyte migration in inflammation existing in the subcutaneous air pocket, and also demonstrated inhibitory activity on the production of TNF-α and IL-10. Through the open field test, it can be deduced that the extracts of B. orellana and its BOSA fraction possibly present molecules that promote myorelaxant and/or sedative action. Furthermore, extracts of B. orellana and its BOSA fraction demonstrate bactericidal action against strains of Staphylococus aureus and Pseudomonas aueaginosa.

COMMITTEE MEMBERS:
Interno - 1674073 - BRUNO GUIMARAES MARINHO
Interno - 4563410 - JULIO ISRAEL FERNANDES
Externo ao Programa - 386960 - WELLINGTON DA SILVA CORTES - UFRRJExterno à Instituição - LUIS FELIPE SOUZA DA SILVA - UFS
Externa à Instituição - MARIANA MARTINS GOMES PINHEIRO - IFRJ