Banca de DEFESA: MARINA SERENO DE FREITAS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : MARINA SERENO DE FREITAS
DATE: 29/02/2024
TIME: 09:00
LOCAL: Online via GoogleMeet
TITLE:

Acetogenin-induced fibrotic heart disease from avocado (Persea americana, Lauraceae) poisoning in horses

KEY WORDS:

Acetogenin; Avocadene 1–acetate; Avocado; Cardiomyopathy; Lauraceae; Persin.

PAGES: 53
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Patologia Animal
SPECIALTY: Anatomia Patologia Animal
SUMMARY:

Poisoning by avocado (Persea americana) has been confirmed in sheep, goats, dogs, rabbits and ostriches. The clinical signs and lesions are attributed to the acetogenin, persin. Little is known regarding the epidemiology, clinical signs, lesions and therapy caused by acetogenin-induced heart damage. During the two-year study, we investigated a horse farm with six horses that often fed themselves with P. americana leaves or mature fruit pulp and skin on the ground. Two horses died, and one underwent necropsy, histopathology, and immunohistochemistry using the anti-cardiac troponin C (cTnC). Grossly and histopathologically, there was severe cardiac fibroplasia. Immunohistochemically, there was a multifocal decrease or negative expression in the cTnC cardiomyocytes' cytoplasm. Persea americana leaves were confirmed in the alimentary tract using botanical anatomy and molecular techniques. The chemical investigation by (LC-ESI-MS) revealed the presence of the acetogenins, persin and avocadene 1-acetate from P. americana. Persin was present in leaves and fruits (seed and pulp), while avocadene 1-acetate was found in leaves and fruits (seed, peel, and pulp) with a higher concentration in the pulp. Four other horses have been examined by electrocardiogram, echocardiogram and serum Troponin 1 (cTnI). To establish a causal effect of consumption of P. Americana and heart fibroplasia in horses, long-time experiments must be carried out.

COMMITTEE MEMBERS:
Presidente - 3701718 - DANIEL GUIMARAES UBIALI
Interno - 1151827 - BRUNO RICARDO SOARES ALBERIGI DA SILVA
Interna - 3247698 - TICIANA DO NASCIMENTO FRANCA
Interno - 387015 - FERNANDO QUEIROZ DE ALMEIDA
Externo ao Programa - 2396528 - LEONARDO RODRIGUES DE LIMA - UFRRJExterno à Instituição - FERNANDO HENRIQUE FURLAN GOUVEIA - UFMT
Externo à Instituição - FÁBIO DE SOUZA MENDONÇA - UFRPE
Externo à Instituição - RICARDO BARBOSA DE LUCENA - UFPB
Externo à Instituição - EDSON MOLETA COLODEL - UFMT