Banca de QUALIFICAÇÃO: PRISCILA SOARES FERREIRA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : PRISCILA SOARES FERREIRA
DATE: 30/04/2025
TIME: 10:00
LOCAL: Google meet
TITLE:

EVALUATION OF THE ASSOCIATION OF MAGNESIUM SULFATE WITH BUPIVACAINE IN REGIONAL BLOCK OF THE QUADRATUMO LUMBAR FOR OVARIOHYSTERECTOMY IN FEMALE DOGS.

KEY WORDS:

analgesia, regional block, pain, adjuvant

PAGES: 66
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Anestesiologia Animal
SUMMARY:

Quadratus lumborum muscle block (QLB), first proposed by Blanco in 2007, is a well-established method in medicine and still under study in veterinary medicine for perioperative analgesia in abdominal surgeries. Additionally, the administration of magnesium sulfate to the local anesthetic prolongs the duration of anesthesia and improves the quality of analgesia in human patients. Thus, the present prospective, randomized, blinded study aimed to evaluate the analgesic effect of bupivacaine alone or in combination with magnesium sulfate (MgSO4) in quadratus lumborum block in female dogs undergoing ovariohysterectomy. Forty-five female dogs were sedated with the combination of acepromazine (0.03 mg/kg) and meperidine (3 mg/kg), intramuscularly. Anesthesia was induced and maintained with intravenous propofol (dose-effect). The female dogs were distributed into 3 treatments (n=15): QLB control group (GS): 0.5 ml/kg/point of 0.9% NaCl; QLB bupivacaine group (GB): 0.25 ml/kg/point of 0.25% Bupivacaine; QLB bupivacaine-magnesium group (GM): 0.25 ml/kg 0.5% Bupivacaine + 0.25 ml/kg/point of 10% MgSO4. During surgery, analgesic supplementation was performed with remifentanil according to cardiovascular parameters (20% increase in heart rate and/or blood pressure, in relation to the measurement at stabilization time). The variables measured were: heart and respiratory rate, blood pressure, temperature, peripheral oxyhemoglobin saturation, carbon dioxide concentration in expired air, remifentanil requirement, propofol requirement, time to first analgesic rescue, number of morphine rescues, number of rescued female dogs, pain assessment using interactive visual analog scale (IVAS) and reduced Glasgow composite scale (GSMPS-SF) and degree of sedation. Statistical analyses were performed using GraphPad Prism software version 6.0 and the significance level established for each test was 5% (P<0.05). The results did not indicate a difference in pain scores (IVAS and GSMPS-SF) and sedation between the groups (P>0.05). Likewise, there was no difference in intraoperative and postoperative analgesic requirements. However, the female dogs in the GS group (130 ± 60.8 minutes) required administration of the first rescue morphine faster than the GB group (450 ± 75.5 minutes) (P<0.05). Regarding heart rate, a significant difference was observed between the GS group and the GB group at the skin incision, with the GS group having a higher value during the transoperative period (P<0.05). However, blood pressure did not follow this difference between the groups. Therefore, based on the results found, it is concluded that treatment with bupivacaine and bupivacaine and MgSO4 administered in the quadratus lumborum block did not promote better analgesia in the intraoperative and postoperative periods.

COMMITTEE MEMBERS:
Interna - 2606155 - VIVIAN DE ASSUNCAO NOGUEIRA CARVALHO
Externo ao Programa - 3000663 - DAVID DO CARMO MALVAR - UFRRJExterna à Instituição - SUZANE LILIAN BEIER - UFMG