Banca de DEFESA: CECILIA AZEVEDO DIAS LOPES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : CECILIA AZEVEDO DIAS LOPES
DATE: 03/12/2025
TIME: 09:00
LOCAL: Instituto de Veterinária
TITLE:

Application of Radiographic Optical Densitometry in the Analysis of Bone Mineral Density in Dogs with Chronic Kidney Disease

KEY WORDS:

mineral and bone disorder, renal secondary hyperparathyroidism, fibrous osteodystrophy, penetrometer

PAGES: 44
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Chronic kidney disease (CKD) is highly prevalent in dogs and frequently leads to the development of mineral and bone disorders (CKD-MBD), compromising bone mineral density (BMD) and the animals’ quality of life. In veterinary medicine, accessible and validated methods for the diagnosis and monitoring of CKD-MBD remain limited. This study evaluated the feasibility of digital optical radiography as a technique for measuring BMD in dogs with CKD and its correlation with serum biomarkers of bone remodeling and renal function. Forty domiciled dogs were included: eight clinically healthy animals (control group) and thirty-two with CKD, equally distributed among stages 1 to 4, according to the International Renal Interest Society (IRIS, 2023) guidelines. Digital radiographs of the mandible (alveolar region and mandibular body base), femur, and second lumbar vertebra were analyzed by digital optical densitometry, calibrated with an aluminum step wedge (penetrometer). Serum analyses included bone-specific alkaline phosphatase, total alkaline phosphatase, urea, creatinine, phosphorus, total calcium, ionized calcium, potassium, sodium, total proteins, and albumin. The radiographic technique showed greater sensitivity in the alveolar mandibular region, differentiating dogs in CKD stages 2, 3, and 4 from the control group. The mandibular body base discriminated only stage 4 from the control group, whereas the femur and second lumbar vertebra showed no significant differences among groups. With increasing CKD stage, progressive and significant increases were observed in serum creatinine, urea, and phosphorus levels. Similarly, bone-specific alkaline phosphatase exhibited a weak negative correlation with mandibular BMD, indicating that higher enzyme values occur in animals with lower bone density. Nevertheless, its values remained within the reference range for all groups, differing significantly only between stage 2 and the control group. It is concluded that digital optical radiography is a feasible, accessible, and low-cost technique for assessing BMD in dogs with CKD, although it shows limited sensitivity for distinguishing among different disease stages. Furthermore, a single measurement of bone-specific alkaline phosphatase did not demonstrate diagnostic value; however, serial measurements, used complementarily to digital optical radiography, may represent a potential tool for monitoring the progression of CKD-MBD.

COMMITTEE MEMBERS:
Presidente - 2572430 - CRISTIANE DIVAN BALDANI
Interno - 4563410 - JULIO ISRAEL FERNANDES
Interno - 1120060 - ALEXANDRE JOSE RODRIGUES BENDAS
Interna - 3324429 - ANDRESA GUIMARAES
Interno - 1151827 - BRUNO RICARDO SOARES ALBERIGI DA SILVA
Externo ao Programa - ***.318.627-** - CRISTIANO CHAVES PESSOA DA VEIGA - UFRRJ
Externa à Instituição - MÁRCIA CAROLINA SALOMÃO SANTOS - UFF
Externo à Instituição - LEONARDO LARA E LANNA - UFJF
Externa à Instituição - MARIA CRISTINA NOBRE E CASTRO - UFF
Externa à Instituição - KARINA YUKIE HIRATA - UFJF