Banca de DEFESA: LARA PATRICIA SANTOS CARRASCO
Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.DISCENTE : LARA PATRICIA SANTOS CARRASCO
DATA : 12/02/2020
HORA: 14:00
LOCAL: Instituo de Veterinária - Salão Verde
TÍTULO:
VIABILITY OF THE EFFECT OF THE THERAPEUTIC PROTOCOL ASSOCIATED WITH GLUCAGON HORMONE, METHODONA, PRAZOSINE, AND INTENSE FLUIDOTERAPY IN DOMESTIC CATS WITH URETERAL STONES
PALAVRAS-CHAVES:
feline, utereterolithiasis, conservative treatment
PÁGINAS: 60
GRANDE ÁREA: Ciências Agrárias
ÁREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
ESPECIALIDADE: Clínica Veterinária
RESUMO:
Ureterolithiasis has been a common cause of feline ureteral obstruction. It is a condition that causes irreversible tissue damage and kidney function when not imperatively resolved. The aim of this study was to evaluate the clinical efficacy of the use of a proto-neck involving methadone analgesia, the use of glucagon hormone to relax the smooth muscle of the ureteral wall and to promote diuresis, furosemide diuretic and α2-adrenergic blocker termine to potentiate the relaxation of the ureteral smooth muscle, reducing the pain associated with ureteral spasms and promoting stone expulsion. Twenty cats with ureterolithiasis without gender and age restrictions were selected. The average age of the cats affected in this study was from 5.8 years to 4.2 years. Most were Non-Defined 16/20 (80%) and four were Persian 4/20 (20%). The main clinical signs at diagnosis were asymptomatic cats who came for routine 8/20 (40%) examinations, 8/20 inappetence (40%), 7/20 prostration (35%), 3/20 vomiting (15%). ), 1/20 hematuria (5%), 3/20 dysuria (15%), 2/20 polyachuria (10%) and 1/20 oliguria (5%). Of the 20 cats, 15 ate wet food, five only ate dry food. Of the animals in this research, four were semidomiciliated and had the act of hunting and 16 lived in flat without hunting. The animals were submitted to the protocol every seven days for 60 days. The cats did not show changes in heart rate, respiratory rate and temperature during the two-hour experiment of all 20 cats evaluated. The glycemic parameter at baseline measured an average of 98 mg / dL, ten minutes after the first administration of glucagon an average of 308 mg / dL, ten minutes after the second administration of glucagon an average of 278 mg / dL and a hour after the end of glucagon administration, an average of 105 mg / dL, showing transient hyperglycemia throughout the experiment. Radiological evaluations were performed on the right lateral and dorsal ventral projections of the abdominal region before starting the protocol and weekly to evaluate and measure the ureterolith displacement in relation to the lumbar vertebrae (L1-L7) and in the dorsal ventral position to detect possible presence and number. of nephrolites. Most cats with calculi were at the height of the L2 vertebra ie in the proximal portion and the last vertebra that was viewed calculus was at the height of the L5. They were also submitted to abdominal ultrasonography at the time of diagnosis, 30 days and 60 days after the start of treatment. Of the 20 cats analyzed 7/20 (35%) presented an increase in the size of the right kidneys and 4/20 (20%) presented a reduction. in the size of the right kidney. In relation to the left kidney 7/20 (35%) presented increase and 3/20 (15%) reduction visualized by abdominal ultrasound examination. The greater number of stones in the ureters did not worsen the hydronephrosis picture in the left and right kidney. It was diagnosed in the 20 animals of this study that 13 (65%) animals with urolith involvement in ureters and kidneys. And seven (35%) animals with urolith involvement were observed only in the ureters
Pelvic dilation improved in 50% of cats from first to third ultra. Of the 20 cats, 13 (65%) had urolith involvement in the left and right kidneys and ureters. Four of the 20 animals were diagnosed with bilateral ureteroliths without renal impairment. The two cats that descended the calculus were two in the range 0.2-0.3 (0.38) and one in the range 0.3-0.4 cm (0.39 cm). Blood samples were collected from all cats before starting the protocol for the evaluation of complete blood count, renal function and electrolyte dosage such as potassium and phosphorus, followed by the renal panel each 15 days, for evaluation. and correlation with the animal's condition. Hematocrit, creatinine, phosphorus and potassium were not statistically related to the 95% confidence level, but urea had correlation statistically with animal survival (P = 0.0014; P <0.05).
MEMBROS DA BANCA:
Presidente - 386998 - HELOISA JUSTEN MOREIRA DE SOUZA
Interna - 2572430 - CRISTIANE DIVAN BALDANI
Externo ao Programa - 387295 - LUIS CARLOS REIS
Externa à Instituição - MÁRCIA CAROLINA SALOMÃO SANTOS - UFF
Externo à Instituição - ANDRÉ LACERDA DE ABREU OLIVEIRA - UENF