EEFFECTS OF FLUIDOTHERAPY REGIMEN, ANESTHETIC PROTOCOL AND VITAMIN C ADMINISTRATION ON VASOPRESSOR REQUIREMENT IN DOGS WITH SEPSIS CAUSED BY PYOMETRA
noradrenaline , sepsis, arterial hypotension
Sepsis induce high incidence in animals causing significant increase of morbidly, mortality and treatment costs. In dogs, pyometra generally initiate signal of sepsis of different intensity. This condition is routine in clinical practice and recognition and early diagnosis of sepsis support treatment in relation to prognostic and costs. Facing this challenge, goal from dogs with ultrasound change suggestive or diagnosed with pyometra: (1) Asses the prevalence of syndrome; (2) correlate epidemiological data, clinicals and laboratories changes, prognosis and mortality with the classification of sepsis in patients e; (3) measure the influence previous administration of ascorbic acid development and management transoperative hypotension from need volemic replacement, inotropic and vasopressors drug requirement. This study will be carried out in female dogs admission in Small Animal Veterinary Hospital Of UFRRJ, in the period of June 2018 to December 2019. These patients will be kepp up with during a whole therapy and will be collected epidemiological and clinical data previously established times. Therapy infused will be defined by the veterinarian according to the patient's need. The classified patients whit sepsis and severe sepsis will be randomly submitted the administration of 500 mg/kg ascorbic acid or placebo. All supportive therapy to patients established before the surgery will be realize as required. After stabilization the patient will be referred for ovariosalpingohisterectomy surgery. The obtained results will be statistically analyze by Shapiro-Wilks test for normality and Analysis of variance for proportion before and after the surgery procedure and between groups with proportions with 95% confidence intervals.