Banca de DEFESA: CARLA MYRRHA CHAVES DUQUE HENRIQUES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
DISCENTE : CARLA MYRRHA CHAVES DUQUE HENRIQUES
DATA : 26/09/2018
HORA: 09:00
LOCAL: Instituto de Veterinária - salão Verde
TÍTULO:

BEHAVIORAL AND NEUROENDOCRINAL CHANGES IN MICE UNDER HYPERCORTISOLEMIA AND HYPOCORTISOLEMIA STATUS

PALAVRAS-CHAVES:

STRESS, THYROID, ADRENALS, MICE

PÁGINAS: 110
GRANDE ÁREA: Ciências Agrárias
ÁREA: Medicina Veterinária
RESUMO:

The stress has been receiving a great focus in the last decades, as being an important precursor of several pathologies, for directly altering the homeostasis. Stress manifestations occur in a variety of ways, be they behavioral or physiological changes. Subjects undergoing stressful situations routinely develop chronic stress, with even more deleterious effects on the body. The constant mobilization of stress mechanisms as occurs during chronic stress is extremely detrimental to the balance of the body, due to the actions of its subtrates in several tissues, and in the long term can cause serious and / or irreversible damages. More and more pathologies have been described as originating from acute or chronic stress, and hypothyroidism may be one of them. It is a disease that affects a great number of individuals. It is important to elucidate if the stress can be a possible inducer of and how it develops. In order to mimic the hyper and hypoactive conditions of the hypothalamus pituitary adreanal axis the animals were submitted to dexamethasone injections during different periods of time, with posterior behavioral and neuroendocrine analysis of the axis hypothalamic pituitary thyroid and hypothalamus pituitary adrenal. Three groups (dexamethasone 10 days + interruption, dexamethasone 10 days, adrenalectomy) were evaluated in all groups with their respective controls. The animals were submitted to behavioral tests (open field, high cross labyrinth, tail suspension and passive avoidance) and the neuroendocrine markers evaluated were corticosterone, TSH and T4.

 

MEMBROS DA BANCA:
Interno - 4563410 - JULIO ISRAEL FERNANDES
Externo ao Programa - 386960 - WELLINGTON DA SILVA CORTES
Externo ao Programa - 2225596 - EMERSON LOPES OLIVARES
Externo à Instituição - FABIO DA SILVA DE AZEVEDO FORTES - UEZO
Externo à Instituição - ANDREA CLAUDIA FREITAS FERREIRA - UFRJ