Banca de DEFESA: ROSEMAR DE ALMEIDA FREITAS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : ROSEMAR DE ALMEIDA FREITAS
DATE: 11/02/2021
TIME: 10:00
LOCAL: plataforma virtual Join Zoom Meeting
TITLE:

Evaluation of the Therapeutic Efficacy of Nutraceuticals in Dissolving Nephrolites in Felines (Felis catus, Linnaeus, 1758)

KEY WORDS:

feline, renal disease, nutraceuticals, clinical

PAGES: 74
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUMMARY:

Nephrolithiasis is a condition frequently seen in feline species, with or without concomitant chronic kidney disease, constituting the major cause of ureteral obstruction as well as progressive lesions to the renal parenchyma. Approximately 90% of nephrolites are composed of calcium oxalate, which cannot be dissolved, and their incidence has increased substantially in recent years, along with recurrence. There are functional foods known as nutraceuticals that provide health benefits. Due to these benefits and the high prevalence of nephrolithiasis in the feline species, the present study aimed to evaluate the therapeutic efficacy of the association of some of these nutraceuticals in the dissolution of these nephrolites. In this study, 51 felines with nephrolithiasis were divided into two groups: control (12 animals) and study (39 animals), where the animals in the control group received a placebo and the study group the nutraceutical formulation. Laboratory tests (blood and urine) and imaging (ultrasound) were performed at intervals of 30 days. To analyze the effectiveness of the treatment between the groups, the prevalence of nephrolytes in the right and left kidneys and the prevalence of nephrolytes between the age groups, the analysis of variance (ANOVA) was used. To test the relationship between the decrease in nephrolites and serum concentrations of magnesium, creatinine and urea, Pearson's correlation tests were conducted and all analyzes were conducted in R (R for Windows 4.0.3) with the aid of the RStudio graphical interface (v1 .3.1093) and the use of FSA v0.8.31 packages; car v3.0-10; agricolae v1.3-3. Regarding the results obtained, the number of females (70.6%) was higher than that of males (29.4%). The age group between 11 and 15 years old had a higher prevalence (39.2%). Mixed breed cats outperformed other breeds (96%). In the assessment of the body condition score (ECC), 60.8% of the cats were within their ideal weight. Regarding intestinal health, only 4% had inflammatory bowel disease. The analysis of variance showed that there was a significant difference between the diameter of the nephrolytes and the period of treatment, indicating a reduction in nephrolytes over time. It was not possible to identify statistical significance of the prevalence of nephrolites between age groups. Pearson's correlation analysis between the variation in the diameter of the nephrolites and the variations in the serum concentrations of magnesium, creatinine and urea did not show any significant differences and although, no significant difference was detected between the diameters of the nephrolites and their presence in the right and left. The nutraceutical compound was shown to be efficient in the dissolution of nephrolites in felines and that time of use did not show a negative influence on the clinic and / or laboratory exams during the entire treatment period.

BANKING MEMBERS:
Presidente - 2606155 - VIVIAN DE ASSUNCAO NOGUEIRA CARVALHO
Interna - 2572430 - CRISTIANE DIVAN BALDANI
Interna - 386998 - HELOISA JUSTEN MOREIRA DE SOUZA
Externo à Instituição - CAROLINA FRANCHI JOÃO - UFU
Externa à Instituição - VALIRIA CERQUEIRA DUARTE