Banca de DEFESA: PRISCILA SOARES FERREIRA
Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.STUDENT : PRISCILA SOARES FERREIRA
DATE: 29/09/2021
TIME: 13:30
LOCAL: Jitsi meet
TITLE:
Influence of the perioperative administration of magnesium sulfate on anesthetized dogs with propofol and fentanyl for ovariohisterectomy.
KEY WORDS:
adjuvant drugs, balanced anesthesia, multimodal anesthesia, nociception, pain, dog.
PAGES: 69
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Anestesiologia Animal
SUMMARY:
Balanced anesthesia involves administering different agents to create an optimal anesthetic state. This approach avoids exclusive dependence on opioids to control intraoperative nociception and postoperative pain. Magnesium sulfate (MgSO4) prevents central sensitization caused by peripheral nociceptive stimulation by acting as an NMDA receptor antagonist, its analgesic and anesthetic-reducing effects have been demonstrated in animal and human models. Thus, the aim of the present study was to evaluate the effect of magnesium sulphate administration on the anesthetic requirement of propofol and fentanyl, on the response to nociceptive stimulus during the intraoperative period and on the immediate postoperative analgesia of bitches undergoing ovariohysterectomy. Thirty-two bitches sedated with acepromazine 0.02 mg/kg intramuscularly, were randomly divided into four groups: PMFA - MgSO4 and high dose fentanyl; PFA - 0.9% NaCl and high dose fentanyl; PMFB - MgSO4 and low dose fentanyl; PFB - 0.9% NaCl and low dose fentanyl. Anesthesia was induced with propofol (1 mg/kg/min) to effect and maintained with continuous rate infusion of selected treatments. Propofol rate was titrated to maintain cardiorespiratory variables within normal range and an adequate anesthetic plan. If a 20% increase in HR, RR or SAP were noted, 2.5mcg/kg fentanyl was administered. The total dose of propofol necessary for anesthetic induction and maintenance was evaluated. Intraoperative antinociceptive effect was assessed through cardiorespiratory variables and the requirement of additional doses of fentanyl. Other variables such as quality of induction, intubation and intraoperative degree of muscle relaxation were evaluated. Time to extubation, head support and spontaneous sternal recumbency were recorded. The quality of anesthetic recovery and pain were assessed using subjective scales. Serum magnesium concentrations were measured at three different time points (pre-, intra- and postoperatively). The present study demonstrated a significant difference among the groups regarding the number of bitches that needed additional doses of fentanyl in the intraoperative period PMFA (4/8) PFA (4/8), PMFB (5/8) and PFB (7/8). There was no significant difference in pain assessment using the Glasgow pain scale in the postoperative period, however, more bitches in the PFB group required analgesic rescue (2/8). The mean serum magnesium concentration was higher in the postoperative than its preoperative values (p <0.005) in the PMFA and PMFB groups. The other variables evaluated did not differ significantly among the groups. This study did not find clear clinical benefits in administering magnesium sulfate in bitches sedated with acepromazine and anesthetized with fentanyl and propofol undergoing ovariohysterectomy.
BANKING MEMBERS:
Interno - 1674073 - BRUNO GUIMARAES MARINHO
Externa à Instituição - LUKIYA SILVA CAMPOS FAVARATO - UFV
Externa à Instituição - SUZANE LILIAN BEIER - UFMG