Banca de DEFESA: PAULA JUNQUEIRA FERRAZ

OZONIOTHERAPY IN THE TREATMENT OF ENDOMETHRITIS IN MARES

Uterine lavage, ozonated saline solution, microbicide.

In mares, endometritis is one of the main causes of embryonic loss and infertility, generating economic and genetic damage to the sector. Ozone therapy with its potential microbicidal effect is an alternative to several conventional treatments. Ozone, due to its high oxidizing capacity, damages the microorganism's membrane, inactivating it in a shorter time and making its recovery unfeasible. Thus, the aim of this study will be to evaluate the effectiveness of uterine infusion of ozonized lactate ranger solution, as well as the use of ozonized PRP (platelet rich plasma) as treatment options for endometritis in mares. For that will be used 30 mares per year diagnosed with endometritis by ultrasound, culture, antibiogram and endometrial cytological examination. The animals will be divided into three groups: G1 (n=10) control= uterine lavage with 1 liter of saline solution; G2 (n=10) = Uterine lavage with 1 liter of ozonized lactated Ringer's solution G3 (n=10) = Ozonized PRP (Platelet Rich Plasma) infusion (40 to 60 ml). Those animals that remain with the infection will be treated with antibiotics according to the result of the antibiogram. The mares evaluated and that are free of infection will be inseminated and the pregnancy diagnosis will be performed 15 days after ovulation to verify the pregnancy rate and consequently the efficiency of the treatments. Data will be analyzed using ANOVA, followed by Tukey's test of means comparison, using a significance of P<0.05.