Banca de DEFESA: MARILAINE CARLOS DE SOUSA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARILAINE CARLOS DE SOUSA
DATE: 07/04/2025
TIME: 09:30
LOCAL: Ambiente virtual RNP conferencia WEB.
TITLE:

Neurological diseases in horses in the state of Bahia.

KEY WORDS:

Asinine, encephalopathies, nervous system, minerais.

PAGES: 76
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Patologia Animal
SPECIALTY: Anatomia Patologia Animal
SUMMARY:

Neuropathies represent an important portion of diseases diagnosed in equids. They are significant causes of economic losses in equids in Brazil and around the world. However, few studies have been conducted with the purpose of characterizing the etiologies of neurological diseases in donkeys. The present study aims to identify the clinical, epidemiological, and pathological characteristics of encephalopathies in northeastern donkeys in the state of Bahia.The animals came from a farm located in Serra Preta, Bahia, where they had lived for about two years, along with other donkeys kept under the same nutritional, sanitary, and environmental management conditions. All the donkeys were vaccinated against rabies and herpes, and were also tested for AIE, with the positive animals being sanitized. Blood samples were collected from all donkeys for complete blood count and biochemical tests. All the animals showed signs of apathy, ataxia, limb abduction, and tongue protrusion. Due to the unfavorable prognosis, they were sent for necropsy.During the necropsy, fragments of liver, kidneys, lungs, spleen, spinal cord, brain, heart, stomach, intestines, and muscles were collected. Additionally, liver samples were collected to measure copper and iron levels. Fragments of the central nervous system (CNS) were collected and sent for direct immunofluorescence (IFD) testing for the rabies virus. In the properties where the animals were previously kept (Euclides da Cunha and Canudos), soil and plant samples were collected to determine the mineral content. Necropsy revealed focal extensive laceration in the upper lip, blackened liver, cerebral edema, and gastric ulcers in all the animals. Microscopically, brown pigment was observed in hepatocytes, cerebral and spinal neurons, renal tubular epithelium, endothelium, and spleen. In the liver, rodanine staining revealed copper. After analyzing the minerals in the liver, a significant presence of iron was found. It was suspected that the excess might have originated from the soil or plants. Therefore, an analysis of the mineral content in the soil and plants was conducted. Despite the collected data, it was not possible to elucidate the cause, although morphological and histological changes were observed. In most of the animals, the concentrations of iron and copper found were below those described in the literature for intoxication cases; only two presented high concentrations of iron in the liver. Consequently, the identified neurological disorders were attributed to encephalopathies resulting from severe liver disease. However, the origin of this liver disease remains unexplained, as iron toxicity did not present enough evidence to be considered a likely cause. Additionally, two articles on neurological diseases and one on neoplasia in equids were prepared, which are included as chapters of the dissertation

COMMITTEE MEMBERS:
Interna - ***.073.401-** - PAULA VELOZO LEAL - UFBA
Externa à Instituição - RAYANE CHITOLINA PUPIN - UFMS
Externo à Instituição - MÚCIO FERNANDO FERRARO DE MENDONÇA - UFBA
Externo à Instituição - TIAGO DA CUNHA PEIXOTO - UFBA