Banca de DEFESA: PRISCILA SOARES FERREIRA
Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.STUDENT : PRISCILA SOARES FERREIRA
DATE: 30/09/2025
TIME: 09:00
LOCAL: Google meet
TITLE:
EVALUATION OF THE ASSOCIATION OF MAGNESIUM SULFATE WITH BUPIVACAINE IN REGIONAL BLOCK OF THE QUADRATUMO LUMBAR FOR OVARIOHYSTERECTOMY IN FEMALE DOGS.
KEY WORDS:
analgesia, regional block, pain, adjuvant
PAGES: 96
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Anestesiologia Animal
SUMMARY:
Quadratus lumborum muscle block (QLB), first proposed by Blanco in 2007, is a well-established method in medicine and still under study in veterinary medicine for intraoperative analgesia in abdominal surgeries. Additionally, the administration of magnesium sulfate to the local anesthetic prolongs the duration of anesthesia and improves the quality of analgesia in human patients. Therefore, this prospective, randomized, blinded study aimed to evaluate the analgesic effect of bupivacaine alone or in combination with magnesium sulfate (MgSO4) in quadratus lumborum block in bitches undergoing ovariohysterectomy. Forty-five bitches were sedated with a combination of acepromazine (0.03 mg/kg) and meperidine (3 mg/kg) intramuscularly. Anesthetic induction and maintenance were performed with intravenous propofol (dose-effectiveness). The bitches were distributed into 3 treatments (n=15): The QLB control group (GS) received 0.9% NaCl 0.5 ml/kg/point; The QLB bupivacaine group (GB) received 0.25 ml/kg of 0.5% bupivacaine + 0.25 ml/kg of 0.9% NaCl per point; and the QLB bupivacaine-magnesium group (GM) received 0.25 ml/kg of 0.5% bupivacaine + 0.25 ml/kg of 10% MgSO4 per point. During surgery, analgesic supplementation was performed with remifentanil according to cardiovascular parameters (20% increase in heart rate and/or blood pressure, in relation to the measurement at stabilization time). The measured variables were: heart and respiratory rate, blood pressure, temperature, peripheral oxyhemoglobin saturation, expired carbon dioxide concentration, remifentanil requirement, propofol requirement, time to first analgesic rescue, number of morphine rescues, number of rescued bitches, pain assessment using the interactive visual analog scale (IVAS) and reduced Glasgow Coma Scale (GSMPS-SF), and degree of sedation. Statistical analyses were performed using GraphPad Prism software, version 6.0, and the significance level was set at 5% (P<0.05) for each test. The results showed no difference between the groups for pain scores (IVAS and GSMPS-SF) or sedation between the groups (P>0.05). However, for the GSMPS-SF score, when compared to the TB, the GM group was the only one to present a significant difference only in the first two evaluated times, only at T0.5h and T1h. Regarding intraoperative and postoperative analgesic requirements, there was no difference between the groups. However, the bitches in the GS group (130 ± 60.8 minutes) required rescue morphine faster than the GB group (450 ± 75.5 minutes) (P<0.05). Regarding heart rate, a significant difference was observed between the GS and GB groups at skin incision, with the GS group having a higher value during the intraoperative period (P<0.05). However, blood pressure did not follow this difference between the groups. Therefore, based on the results found, it is concluded that treatment with bupivacaine and bupivacaine and MgSO4 administered in the quadratus lumborum block did not present robust results that demonstrate better analgesia during the intraoperative and postoperative periods.
COMMITTEE MEMBERS:
Presidente - 1674073 - BRUNO GUIMARAES MARINHO
Externa à Instituição - CLARISSA MARTINS DO RIO MOREIRA
Interno - 2318733 - DANIEL DE ALMEIDA BALTHAZAR
Externo ao Programa - 3000663 - DAVID DO CARMO MALVAR - UFRRJExterno ao Programa - 1519567 - FABIO FAGUNDES DA ROCHA - nullExterno à Instituição - RENATO LEÃO SÁ DE OLIVEIRA - UFV
Externa à Instituição - SUZANE LILIAN BEIER - UFMG
Interna - 2606155 - VIVIAN DE ASSUNCAO NOGUEIRA CARVALHO