USE OF A THERAPEUTIC PROTOCOL USING GLUCAGON HORMONE IN DOMESTIC CATS WITH URETERAL STONE.
felines, utereterolithiasis, conservative treatment
Ureterolithiasis has been a common cause of feline ureteral obstruction. It is a condition that causes irreversible tissue damage and kidney function when not imperatively resolved. We aimed to evaluate the clinical efficacy of the use of a protocol involving methadone analgesia, the use of glucagon hormone to relax the ureteral smooth muscle, the furosemide diuretic and the α2 adrenergic blocker to enhance the relaxation of the ureteral smooth muscle, reducing the pain associated with ureteral spasms and promoting expulsion of the stone.Twenty cats with ureterolithiasis will be selected, without restrictions on gender and age. The animals will be submitted to the protocol every seven days for 60 days. All cats will be monitored for parameters such as heart rate, respiratory rate, blood glucose, before and after the protocol, as well as observing possible adverse effects such as salivation, vomiting, tachypnea, hyperglycemia. Radiological evaluations will be performed on the right lateral and dorsal ventral projections of the abdominal region before starting the protocol and weekly to evaluate and measure the ureterolith displacement in relation to the lumbar vertebrae (L1-L7) and in the dorsal ventral position to detect possible presence and number. of nephrolites. They will also undergo abdominal ultrasound at the time of diagnosis, 30 days and 60 days after the start of treatment. Blood samples will be collected from all cats before starting the protocol for evaluation of complete blood count, renal function and electrolyte dosage such as potassium and phosphorus, followed by the renal panel with a frequency of 15 days.