Banca de QUALIFICAÇÃO: THIAGO SOUZA COSTA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : THIAGO SOUZA COSTA
DATE: 02/12/2020
TIME: 14:00
LOCAL: Laboratório de Quimioterapia Experimental em Parasitologia Veterinária (On line)
TITLE:

Alternative protocol using lomustine to treat canine transmissible venereal tumor

KEY WORDS:

Keywords: Chemotherapy; neoplasm; antineoplastic treatment; alkylating agent; dogs.

PAGES: 50
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

The canine transmissible venereal tumor (TVTC) is one of the most common neoplasia in dogs in developing countries, affecting mainly animals with free access to the street, since it is predominantly transmitted through coitus. The treatment consists in the use of intravenous vincristine sulfate, with weekly intervals, which often makes it difficult to continue and currently makes it impossible in most Veterinary Medical establishments that are not equipped according to the current legislation for the treatment. practice of antineoplastic therapy services. Another important regarding point is the frequent reports of tumor resistance in view of the chemotherapy protocol of choice, which shows the need to search effective alternatives for the treatment of TVTC. Lomustine is a chemotherapeutic agent of alkylating class that is orally administered, with a 21 days interval application, which would facilitate owners adherence to treatment of animals affected by TVTC. The study aims to evaluate the effectiveness of lomustine as an alternative in the treatment of TVTC. For this, twelve animals with cytopathological diagnosis of TVTC in the genital region and or with inguinal lymph nodes metastasis were selected, regardless of sex or age. The animals were treated with lomustine at doses ranging from 75 to 90 mg / m² orally, every 21 days, using as criteria for clinical cure the total remission of the neoplasia and negative cytopathological examination for the presence of neoplastic cells in the tumor area. Of the twelve animals submitted to the chemotherapy treatment protocol, seven achieved clinical and cytopathological cure of the lesions, one showed partial remission of the lesions, and four showed an unsatisfactory response to treatment.

BANKING MEMBERS:
Presidente - 4563410 - JULIO ISRAEL FERNANDES
Interno - 2318733 - DANIEL DE ALMEIDA BALTHAZAR
Externo à Instituição - MARIANA BEZERRA MASCARENHAS - UFRRJ
Externa à Instituição - REGINA HELENA RUCKERT RAMADINHA - UFRRJ