Banca de QUALIFICAÇÃO: GABRIELLY FERREIRA SANTOS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : GABRIELLY FERREIRA SANTOS
DATE: 19/12/2023
TIME: 14:00
LOCAL: Online - Google Meet
TITLE:

MACROSCOPIC AND MICROBIOLOGICAL PULMONARY CHANGES IN DOGS WITH DIROFILARIOSIS

KEY WORDS:

dyspnea, endoscopy, filaria, cough

PAGES: 25
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Heartworm disease is a zoonosis, caused by the nematode Dirofilaria immitis, and is transmitted by mosquitoes of the Culicidae family. It is a complex and potentially fatal cardiopulmonary disease, with a chronic course and progressive evolution, but can occur acutely in highly parasitized animals. The parasite is preferentially located in the pulmonary arteries, generating an inflammatory process throughout the vascular endothelium and lung parenchyma due to its physical presence and movement. Furthermore, surface antigens from Wolbachia bacteria, an endosymbiont of D. immitis, can be released, which contributes to increasing the inflammatory process. There is evidence that the inflammatory lung disease associated with the presence of D. immitis is actually more related to the presence of Wolbachiae than the inflammatory effects caused by it remain even after the elimination of the adult parasites. Initially, the infection may be asymptomatic, gradually and progressively; and begin to present clinical manifestations such as chronic cough, change in breathing pattern, exercise intolerance, anorexia, syncope, among others. Diagnosis is based on the detection of circulating antigens of the adult parasite using ELISA and immunochromatography techniques in addition to microfilariae research. Imaging tests such as radiography and echocardiography allow us to observe cardiopulmonary changes caused by the filaridium, establishing the severity of the infection. Since the adulticidal treatment recommended for dogs with heartworm disease is not available in Brazil, it is recommended to use an alternative treatment that combines the use of a drug from the macrocyclic lactone class associated with doxycycline. The objective of this study is to dynamically evaluate macroscopic and cytological lung changes from the occult phase of the disease, through bronchoscopy, in dogs diagnosed with heartworm disease.

COMMITTEE MEMBERS:
Presidente - 1120060 - ALEXANDRE JOSE RODRIGUES BENDAS
Interno - 1151827 - BRUNO RICARDO SOARES ALBERIGI DA SILVA
Externo ao Programa - ***.318.627-** - CRISTIANO CHAVES PESSOA DA VEIGA - UFRRJ