Banca de DEFESA: MATHEUS DAUDT MATOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MATHEUS DAUDT MATOS
DATE: 01/03/2024
TIME: 09:00
LOCAL: Sala 54 - Instituto de Veterinaria
TITLE:

Ultrasonographic evaluation of cats naturally infected by Platynosomum illiciens, before and after treatment with praziquantel

KEY WORDS:

Platinosomosis, liver, cholangitis, cat, treatment.

PAGES: 25
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Platinosomosis is the nomenclature used to refer to infection by the trematode Platynosomum spp. Infections occur mainly in felines. The parasite's life cycle includes the presence of three intermediate hosts (snails, terrestrial isopods, geckos or frogs). The cat is considered the definitive host of the parasite and acquires the infection by ingesting a vertebrate intermediate host containing metacercariae. Infected cats may be asymptomatic or show signs such as vomiting, diarrhea and jaundice. Laboratory tests related to liver function and damage and ultrasound can lead to diagnostic suspicion, which is confirmed through parasitological examination of feces or bile. The treatment for the infection is praziquantel. The present work aims to evaluate possible ultrasound changes before and 30 days after treatment with praziquantel (20mg/kg/3days), in the ultrasound appearance of the liver and bile ducts of cats parasitized by Platynossomum sp. Descriptive statistics were performed for numerical variables. The Shapiro-Wilk normality test was applied to evaluate the normality of the variables, with normal values being considered those with a p value>0.05. The T (student) and Wilcoxon tests were applied to compare means for parametric and non-parametric variables, respectively. The Chi-Square test was used to compare the frequencies of hepatobiliary changes detected on ultrasound and biochemical tests. The analyzes were carried out at a significance level of 95%, using the BioEstat® 5.0 program. Therefore, 10 cats underwent abdominal ultrasound examination with emphasis on the hepatobiliary system and underwent hematological and biochemical tests for liver evaluation before and 30 days after treatment using praziquantel. When comparing the ultrasound examination before and after treatment, changes were detected such as the presence of biliary sludge in the gallbladder (5/10), the cystic duct was visible in five animals, of which only 3 showed an increase in its diameter, 40% of the animals showed periductal reactivity, 70% showed decreased hepatic echogenicity, the other parameters evaluated were within normal limits. After treatment with praziquantel, a statistical difference was observed only in the height of the duodenal papilla (t=-4.8595, p=0.0009). The hematological evaluation revealed that the mean hematimetric parameters before and after treatment remained within the reference values for the species, as well as biochemical analyses, where total plasma proteins showed their mean value slightly increased on day 0 (8.6 - 1.7 g/dL) and on day 30 (8.72 - 1.12 g/dL). In the present study, it was possible to conclude that the cats evaluated naturally infected by Platynosomum sp. presented ultrasound changes related to the hepatobiliary system such as the contents in the gallbladder and bile ducts, liver echogenicity and presence of periductal reactivity.; duodenal papilla height was the only ultrasound parameter that showed a difference in ultrasound exams 30 days later, but without any significant clinical correlation; ultrasound changes were more frequent than blood changes to detect changes in the hepatobiliary system in cats naturally infected by Platynossomum sp. on Day 0 and after treatment with praziquantel (20mg/kg/3days) on Day 30.

COMMITTEE MEMBERS:
Interno - 1151827 - BRUNO RICARDO SOARES ALBERIGI DA SILVA
Interna - 2572430 - CRISTIANE DIVAN BALDANI
Interno - 4563410 - JULIO ISRAEL FERNANDES
Externa à Instituição - ELAN CARDOZO PAES DE ALMEIDA - UFF
Externo à Instituição - FLAVYA MENDES DE ALMEIDA - UFF