Banca de QUALIFICAÇÃO: NATHALI ROBERTA ALVES DOS SANTOS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : NATHALI ROBERTA ALVES DOS SANTOS
DATE: 04/02/2026
TIME: 08:00
LOCAL: Online
TITLE:

Evaluation of the effects of beclomethasone dipropionate in dogs with tracheal collapse

 

 

KEY WORDS:

Beclomethasone, Canine, Tracheal colapse

PAGES: 24
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUMMARY:

Tracheal collapse is a progressive, degenerative disease characterized by narrowing of the tracheal
lumen, which occurs due to degeneration of the cartilage and laxity of the dorsal tracheal muscle,
interfering with the flow of air to the lungs. It usually affects small-breed, miniature or toy dogs from
middle age to the elderly. The symptoms involve a chronic, paroxysmal, unproductive cough causing
respiratory distress, dyspnea, exercise intolerance and cyanosis. Diagnosis is made through a
combination of clinical history, physical examination and imaging tests. On physical examination,
respiratory distress can be observed and abnormal respiratory sounds can be heard on auscultation of
the trachea and lungs. X-rays can show narrowing of the tracheal lumen in the cervical or thoracic
region. Clinical treatment is indicated for cases of grade I and II tracheal collapse and mild clinical
signs, but it is palliative as it only reduces the clinical signs and improves the animal's respiratory
capacity and well-being. Surgical treatment is indicated for dogs that have more than 50% loss of
tracheal lumen and do not respond to clinical treatment. Inhalation of glucorticoid-based drugs is often
used to treat obstructive lung diseases such as asthma and also to treat tracheal collapse. This route
provides a lower systemic concentration of the drug, thus reducing side effects. However, prolonged
use of the drug can generate adverse effects in various systems. Therefore, the proposed study aims to
evaluate the effect of beclomethasone in the treatment of tracheal collapse in dogs. The study will
include 14 dogs diagnosed with tracheal collapse by radiography or endoscopy of the airways. The
animals included will undergo a clinical examination (history, anamnesis and physical examination),
will be weighed and their body condition score determined and will then be divided into two groups, a
control group (Gsal) which will receive treatment with nebulized 0.9% saline solution and a treatment
group (Gbeclo) which will receive treatment with nebulized beclomethasone dipropionate (DPB) at a
dose of 200μg (1ml) diluted in 4mL of saline solution and nebulized using a nebulizer every 12h for 7
days. A clinical examination of the animal will be carried out before and after the treatment to assess

the clinical effects of the treatment. The data will be stored in a computerized database using MS-
Excel software. The database will contain the registration data of each animal and the results obtained

will be subjected to statistical analysis pertinent to epidemiological studies. Thus, it is hoped that this
study will demonstrate a relevant result of the use of the drug and provide clinical support,
demonstrating the efficacy or otherwise of the treatment, as well as contributing to the clinical
management of the disease.

 

COMMITTEE MEMBERS:
Interno - 1674073 - BRUNO GUIMARAES MARINHO
Interno - 1151827 - BRUNO RICARDO SOARES ALBERIGI DA SILVA
Interno - 387015 - FERNANDO QUEIROZ DE ALMEIDA