EVALUATION OF ALTERNATIVE DOSE OF IVERMECTIN IN THE SLOWKILL PROTOCOL FOR THE TREATMENT OF DOGS NATURALLY INFECTED BY Dirofilaria immitis.
heartworm, canines, helminths.
Dirofilaria immitis (LEIDY & J., 1856) is a nematode whose main habitat is the pulmonary
arteries and right heart chambers of canids. It is the etiological agent of clinical signs such as
cough and dyspnea, generally associated with lung parenchymal disease. All individuals of the
species D. immitis depend on bacteria of the genus Wolbachia to maintain their basic functions.
The recommended alternative adulticidal treatment consists of the combination of doxycycline
in high doses (10mg/kg/BID/28 DAYS) associated with macrocyclic lactones from the
milbemycin group (slow kill protocol). Aiming to evaluate the effectiveness of an adulticidal
treatment that is less aggressive to the patients' digestive tract and of lower value, we propose
the association of doxycycline at a recommended dose (10mg/kg/SID/28DAYS) with
macrocyclic lactone from the avermectin group (ivermectin) at a dose high (100mcg/kg/month).
30 dogs naturally infected by D. immitis will be included. The animals will be followed for 24
months or until they are considered cured or removed from the study.