Banca de DEFESA: ISABELLE VILELA BONFIM

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ISABELLE VILELA BONFIM
DATE: 23/02/2024
TIME: 09:00
LOCAL: Auditório Biblioteca Central UFRRJ
TITLE:

Development of fipronil chewable tablets, descriptive pharmacokinetics and efficacy against Cochliomyia hominivorax larvae in naturally infested dogs. 

KEY WORDS:

Parasitology, Fipronil, Pharmacokinetics, Efficacy.

PAGES: 87
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Medicina Veterinária Preventiva
SPECIALTY: Doenças Parasitárias de Animais
SUMMARY:

Among the main ectoparasites of importance in companion animals, the flies Cochliomyia hominivorax stand out. Several classes of insecticides are used to manage infestations. Fipronil is an insecticide belonging to the phenylpyrazole class, used topically in veterinary medicine. Due to data on human exposure to FIP used through this route of administration, coupled with the trend in the veterinary market towards the development of oral ectoparasiticides, the present study aimed to develop a formulation in the pharmaceutical form of chewable tablets containing fipronil. , with evaluation of the descriptive pharmacokinetics of oral treatment and efficacy in dogs naturally infested with C. hominivorax larvae. The tablets were developed by molding, following the steps of preparing the diluent, binder, mixing the components and incorporating the active ingredient. The pharmacokinetic study was carried out after the oral administration of one unit of fipronil chewable tablet at 72mg, corresponding to 6mg/kg. The efficacy study was conducted through the oral administration of one unit of fipronil chewable tablet at 72mg, according to the natural occurrence of dogs infested by C. hominivorax. The characterization of the tablets was acceptable in relation to quality control criteria, with average weight, dosage and dose uniformity within acceptable limits. When administered orally, it was absorbed and reached systemic concentration quickly, with a Cmax of 3126.53 ng/mL in 2.22h (Tmax). The in vivo clinical efficacy study with the treatment of one unit of the 72mg fiprinil chewable tablet promoted the elimination of 97.76% of C. hominivorax larvae after 24 hours of treatment, with an overall efficacy of 100% in naturally infested dogs.

 

COMMITTEE MEMBERS:
Presidente - 1700427 - YARA PELUSO CID
Interno - 1173660 - FABIO BARBOUR SCOTT
Externo à Instituição - DIEGO FONTANA DE ANDRADE - UFRGS
Externo à Instituição - ISABELLA VILHENA FREIRE MARTINS - UFES