Banca de DEFESA: FABIANA BRANDÃO DE OLIVEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : FABIANA BRANDÃO DE OLIVEIRA
DATE: 15/12/2025
TIME: 09:00
LOCAL: Defesa em formato on-line
TITLE:

Clinical and laboratory monitoring of dogs with Visceral Leishmaniasis treated with Miltefosine combined with Allopurinol

KEY WORDS:

Leishmania infantum; relapse; miltefosine; allopurinol; therapeutic response

PAGES: 56
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Canine Visceral Leishmaniasis (CVL), caused by Leishmania infantum, is an endemic zoonosis in Brazil, with domestic dogs serving as the primary reservoir. Treatment remains challenging, as therapeutic efforts aim to control clinical manifestations and improve quality of life, while parasitological cure is rarely achieved. Since 2016, miltefosine has been adopted as the standard therapy in the country. This retrospective study aimed to evaluate the therapeutic response of dogs with CVL treated with miltefosine combined with allopurinol, based on systematic clinical and laboratory monitoring. Thirty medical records were selected from an initial set of 72 files from a veterinary clinic in Volta Redonda, RJ, according to predefined inclusion criteria. Dogs received miltefosine (2 mg/kg, PO, for 28 days) and allopurinol (10 mg/kg, PO, every 12 hours, for 120 days). Evaluations were conducted at D0, D+60, and D+120. Progressive clinical improvement was observed throughout treatment. At D0, the most frequent findings included dermatopathies, lymphadenomegaly, and splenomegaly. By D+120, signs such as anorexia, weight loss, polyuria/polydipsia, and epistaxis showed marked reduction, whereas articular alterations and residual dermatological signs persisted in some animals. Laboratory analyses at D0 revealed non-regenerative anemia and a mean creatinine level of 2.05 mg/dL. Hematological and biochemical parameters stabilized during follow-up, with notable improvement in erythrocytic indices by D+60. At D+120, mean creatinine values remained at or slightly above the upper reference limit. Overall, the combined therapy with miltefosine and allopurinol resulted in satisfactory clinical control and decreased parasite burden, highlighting the importance of continuous clinical and laboratory monitoring in the therapeutic management of CVL

COMMITTEE MEMBERS:
Presidente - 4563410 - JULIO ISRAEL FERNANDES
Interno - 1151827 - BRUNO RICARDO SOARES ALBERIGI DA SILVA
Interno - ***.088.737-** - DIEFREY RIBEIRO CAMPOS - UFRRJ
Externo à Instituição - ARY ELIAS ABOUD DUTRA - UVA
Externa à Instituição - LILIAN BATISTA DA SILVA