Banca de DEFESA: PALOMA MATHIAS DO NASCIMENTO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : PALOMA MATHIAS DO NASCIMENTO
DATE: 04/03/2022
TIME: 14:00
LOCAL: meet.google.com/kqp-rozy-oyt
TITLE:

SCREENING OF ACTIVE PHYTOPHARMACEITUCAL INGREDIENT WITH ANTIHELMINTIC POTENTIAL USING THE  Caenorhabditis elegans MODEL 

KEY WORDS:

Essential oils, Antiparasitic, Selection

PAGES: 127
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Livestock productivity can be significantly diminished by the effects of gastrointestinal parasitism. As well, it can impact dogs and cats and, consequently, humans due to its zoonotic potential. The need for food without pesticide residues, better working conditions and an increase in cases of anthelmintic resistance opens the way for sustainable alternatives in the control of helminthiases, such as essential oils. In this context, Caenorhabditis elegans is used to research phytoinputs with anthelmintic activity at different stages of development through toxicological evaluation in different strains of C. elegans. The aim of the present study was to evaluate the activities of essential oils against C.elegans and thus to assess their potential for use as an anthelmintic product. The following EOs were used: Cymbopogon flexuosus, Eugenia caryophyllus, Illicium verum, Mentha piperita, Mentha spicata, Pelargonium graveolens and Thymus vulgaris. These were solubilized in DMSO. In vitro lethality tests were carried out on adults of wild strain (N2) and strains resistant to ivermectin, albendazole and levamisole, egg hatchability and egg laying. The essential oil of Illicium verum showed better nematicidal activity in N2 adults and inhibition of egg laying. On the other hand, the essential oil of Pelargonium graveolens exhibited better inhibition of egg hatching. In general, compared to the N2 strain, the essential oils of I. verum, P. graveolens and T. vulgaris showed sensitivity at different degrees of concentrations. However, in ivermectin-resistant strains and exposed to high concentrations in the levamisole-resistant strain, P. graveolens essential oil did not exhibit efficacy.

BANKING MEMBERS:
Presidente - 1173660 - FABIO BARBOUR SCOTT
Interno - 1705075 - DOUGLAS SIQUEIRA DE ALMEIDA CHAVES
Interna - 2929889 - THAIS RIBEIRO CORREIA AZEVEDO
Externo à Instituição - CAIO MÁRCIO DE OLIVEIRA MONTEIRO
Externo à Instituição - GUILHERME MARCONDES KLAFKE
Externa à Instituição - VIVIANE DE SOUZA MAGALHAES