Banca de DEFESA: LARITSSA ANDRADE PINHEIRO MAGALHAES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LARITSSA ANDRADE PINHEIRO MAGALHAES
DATE: 26/02/2025
TIME: 13:00
LOCAL: Sala Prof. Laerte Grisi/ https://meet.google.com/eea-nqkf-qdq
TITLE:

Efficacy of Orally Administered Fluralaner in Paste Formulation for the Control of Dermacentor nitens in Brazilian Pony Horses (Stall Test)

KEY WORDS:

ticks; isoxazolines; horses

PAGES: 67
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUMMARY:

The aim of this study was to evaluate the effectiveness of a paste formulation containing Fluralaner in controlling D. nitens in horses. Fluralaner is a relatively new drug belonging to the isoxazoline class, whose mechanism of action is to block chloride channels controlled by aminobutyric acid (GABA) and chloride channels controlled by glutamate. This drug was administered orally at a dose of 25mg/kg body weight. The study was carried out using a stable test, where 14 Brazilian Pony horses were stabled and divided into a treated group and a control group, animals that received the formulation and animals that did not receive the formulation, respectively. Both groups underwent periodic infestations on days -31, -29, -27, -25, -23, -21, -19, -17, -15, -13, -11, -9, -7, -5, -3, -1. Naturally shed ticks were collected from day -3 to day +29. The average number of ticks shed three days before treatment (-3, -2, -1) was 71.0±48.5 for the animals in the control group and 81.8±66.1 for the animals in the treated group. These data showed no statistically significant differences (p=0.831), which shows that the groups were randomized homogeneously. Comparing the means from D+1 to +29, there was a significant difference (p=0.024) and a high effect size of 1.528 (0.189 - 2.810). The averages for this observation period were 36.4 (4.5-77.9) and 8.3 (3.6 - 20.1) for the control and treated groups, respectively. Disregarding the values obtained for tick drop on day +1, a measure adopted due to zero tick efficacy at this time, the following average tick values were obtained after this time for the period from D+2 to D+29: 33.9 (2.6-71.5) and 1.9 (0.9 to 4.1). There was a significant difference (p<0.0001) and a large effect size of 2.651 (1.009 to 4.229). The tick efficacy for the period from D+1 to +29 was 80.2%. When looking at the tick drop values from day +1 and consequently the efficacy, it can be concluded that it is correlated to the 0 (zero) efficacy of this time. Tick efficacy for the period from D+2 to +29, disregarding D+1, was 95.1%. When looking at the tick drop values on day +1 and, consequently, the efficacy, it can be concluded that it is correlated to the 0 (zero) efficacy of this time. With regard to the results of the action of fluralaner observed in this study on the reproductive aspects of D. nitens, it can be seen that there were significant differences between the average values for the weight of teleogyns, laying weight and percentage of larvae hatching for the two experimental groups.

COMMITTEE MEMBERS:
Presidente - 1173660 - FABIO BARBOUR SCOTT
Interna - 2929889 - THAIS RIBEIRO CORREIA AZEVEDO
Externo à Instituição - FERNANDO DE ALMEIDA BORGES - UFMS
Externo à Instituição - JOSE RECK JUNIOR - OUTRO
Externo à Instituição - LIVIO MARTINS COSTA JUNIOR - UFMA