Banca de QUALIFICAÇÃO: MARÍLIA ALVES MACHADO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : MARÍLIA ALVES MACHADO
DATE: 31/03/2021
TIME: 09:00
LOCAL: Laboratório de Quimioterapia Experimental em Parasitologia Veterinária (On line)
TITLE:

CONTRIBUTION OF ISOXAZOLINS TO THE TREATMENT OF NATURALLY INFESTED

 RABBITS BY Psoroptes ovis And Leporacarus gibbus

KEY WORDS:

Key words: dermatopathies, otitis, parasites, therapy

PAGES: 50
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Dermatopathies are commonly observed in rabbits caused by ectoparasites, mainly Psoroptes ovis and Leporacarus gibbus, responsible for developing otitis externa and the presence of black spots on the fur, respectively. Although several treatments have already been described for the control of parasites in rabbits, new compounds and routes of administration are objectives of studies, with the aim of developing safer and more practical products for use. However, the present study aimed to evaluate the efficacy of a group of molecules, isoxazolines (afoxolaner, fluralaner, lotilaner and sarolaner), in controlling psoroptic mange and infestation by L. gibbus in naturally infested rabbits. To determine the effectiveness, clinical (determined by the score of the lesions: 1 to 4) and parasitological (through the evaluation of crusts and fur: on days 0, +3, +7, +14, +21, +28 and + 35). A total of 36 rabbits infested with both mites will be used throughout the experiment. Divided into 5 experimental groups and 1 control group. So far, 2 groups have been executed. The animals were clinically evaluated for lesional score and subjected to parasitological examination on days 0, +3, +7, +21, +28 and +35 post medication, with 1 group receiving fluralaner therapy at a dose of 25mg / kg and another group was medicated with lotilaner at a dose of 20mg / kg, both were treated orally in a single dose. The control group was submitted to the same evaluation and examination procedures, using placebo medication. Thus, it will occur with all other groups to be treated. Those treated with fluralaner after 72 hours were found to be negative in the parasitological examination for both mites. Those treated with fluralaner after 72 hours were found to be negative in the parasitological examination for both mites. The rabbits treated with lotilaner, after 72 hours, only 2 animals presented live mites in the parasitological exam for P. ovis and 1 positive rabbit for L. gibbus. In both groups, no adverse clinical reactions were observed. It is expected to prove that this new class can be used in rabbits, being an alternative for the treatment of these mites in this species.

BANKING MEMBERS:
Externo ao Programa - 2318733 - DANIEL DE ALMEIDA BALTHAZAR
Externa à Instituição - FLÁVIA CLARE GOULART DE CARVALHO
Externo à Instituição - MARIANA BEZERRA MASCARENHAS - UFRRJ
Externa à Instituição - RENATA RIBEIRO NOVAIS DE CARVALHO - UFRRJ