Banca de DEFESA: RAFAELLA TORTORIELLO BARBOSA SAMPAIO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RAFAELLA TORTORIELLO BARBOSA SAMPAIO
DATE: 29/09/2021
TIME: 16:00
LOCAL: Defesa em modalidade virtual (Google meet)
TITLE:

Efficacy of Lotilaner in the treatment of Dermatobia Hominis (diptera: cuterebridae) in naturally infested dogs

KEY WORDS:

Human bot-fly, Lotilaner, Larvicide

PAGES: 58
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

The human bot-fly cause skin lesions known as dermatobiosis. These are intensely uncomfortable, painful and the concomitant presence of bacterial infections and myiasis causes recording of the condition. Effective treatment should eliminate or kill existing larvae and promote wound healing as early as possible. Manual extraction of larvae by digital pressure and the most used treatment method, however, can cause intense discomfort to the animal. Safe, painless and effective therapy has encouraged the search for new pharmaceutical options. The aim of this study was to evaluate the efficacy of lotilaner in the control of D. hominis in naturally infected dogs. For the evaluations, 12 dogs, of a defined breed, aged between one and ten years old, of both sexes, weighing between 10 and 20 kg, with at least three larvae in each, located in any region of the body, were used. The individuals were medicated with lotilaner, following the recommendations of the package insert for the treatment of other ectoparasitosis, at a minimum dose of 20 mg/kg, administered orally in a single dose. After administration, the animals remained in the home environment, where the evaluation and larval removal was carried out with +6 hours to verify the activity provided by the medication. Larvae that showed minimal motility after removal were considered alive. The lotilaner efficacy was calculated by the following formula: [100 x (number of dead larvae - number of live larvae) / total number of larvae]. Nineteen live larvae were recovered, representing an efficacy of 80.6% six hours after the administration of isoxazoline lotilaner. It is noteworthy that the other recovered larvae showed mild motility, suggesting that the effectiveness could be greater if removal was performed at a later period. It is concluded that lotilaner administered orally in a single dose of 20mg/kg was effective in controlling D. hominis in naturally infected dogs

BANKING MEMBERS:
Presidente - 4563410 - JULIO ISRAEL FERNANDES
Interna - 2456316 - KATHERINA COUMENDOUROS
Interna - 2929889 - THAIS RIBEIRO CORREIA AZEVEDO
Externo ao Programa - 1120060 - ALEXANDRE JOSE RODRIGUES BENDAS
Externo à Instituição - ANDRE LUIZ RODRIGUES ROQUE - FIOCRUZ
Externo à Instituição - ARY ELIAS ABOUD DUTRA - UVA