Adherence and persistence to adjuvant endocrine therapy for breast cancer: a systematic review of psychological interventions and psychosocial factors
Adjunctive drug therapy, psychosocial intervention, treatment adherence.
Breast cancer (BC) is the most prevalent type of cancer in women, with a high number of cases and deaths. Among the existing types of tumors, those positive for hormone receptors are the most prevalent. Therefore, treatment with endocrine therapy (ET) is recommended adjuvantly for a period of 5 to 10 years to prevent recurrence and reduce the number of deaths. However, adherence and persistence are still considered suboptimal, so that in this process several factors are involved. Psychosocial factors are those related to the patient and her social context, and can be modified through interventions. Previous literature reviews have mostly addressed interventions aimed at educating and informing the patient, with little significant result. Considering the positive effects that Psychological Interventions (PIs) have generated in several contexts, this work aims to conduct a systematic review of PIs that aim to improve adherence and persistence of endocrine treatment. For this purpose, randomized controlled or uncontrolled clinical trials will be considered. It is expected to find studies with truly effective interventions, in order to assist health professionals in the future.