Banca de DEFESA: SAMANTHA COSTA AMORIM MUNIZ

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : SAMANTHA COSTA AMORIM MUNIZ
DATA : 26/02/2019
HORA: 13:00
LOCAL: Programa de Pós-graduação em Ciências Fisiológicas
TÍTULO:

Study of the anxiolytic and antidepressant actions of essential oil of Schinus molle L.

PALAVRAS-CHAVES:

mood disorders, medicinal plants, sedation

PÁGINAS: 41
GRANDE ÁREA: Ciências Biológicas
ÁREA: Farmacologia
SUBÁREA: Etnofarmacologia
RESUMO:

Anxiety disorders and depression are among the most prevalent mental disorders in the population, affecting thousands of people around the world. Folk medicine, a very old practice, makes use of several plants for the purpose of treating diseases that affect man. Over the years there has been a great advance in the studies of medicinal plants to obtain new compounds with therapeutic properties. Schinus molle L., plant belonging to the family Anacardiaceae, is popularly known as aroeira. In addition to presenting a wide range of biological activities, its ethanolic and hexanic extract showed to have antidepressant effect. The objective of this project was to evaluate the anxiolytic and antidepressant actions of the essential oil of the leaves of Schinus molle L. (OEFS) in animal models. In the open field  test (AC), OEFS at a concentration of 100 mg/kg reduced the number of quadrants traveled (OES100 = 19.1 ± 6.2 vs. CT = 71.4 ± 3.3) as well as the number of rearings (OES100 = 1 ± 0.5 vs. CT = 22.5 ± 10.5). In the test of the rotating bar, the OESF did not present significant difference in the time of permanence in the bar and number of falls. In the test of sleep induced by etomidate, OESF100 showed an increase in total sleep recovery time in relation to the control group (OES100 = 162.2 ± 14.9 vs. CT = 97.4 ± 7.3 s). To evaluate the possible anxiolytic effect, the doses of 25 and 50 mg / kg OEFS were used in the elevated plus maze (LCE) and in the MARBLE BURYING test (TEE). In LCE, OEFS did not present significant difference in any of the parameters analyzed (percentage of time in open arms and percentage of open arms entries). In the TEE, OEFS did not reduce the number of Glass marbles burying in relation to the control group. For the evaluation of a possible like-antidepressant effect of OEFS, the forced swimming test (NF) was performed. OEFS did not reduce the immobility time at any of the doses tested (25, and 50mg/kg). Pretreatment with flumazenil was not able to reverse the reduction of locomotor and exploratory activity of the animal in CA caused by OEFS100, showing that the depressant effect is not mediated by the benzodiazepine site of the GABAA receptor. Further studies are needed for further investigation of its sedative effect, as well as better exploration of the pharmacological profile of this plant.

MEMBROS DA BANCA:
Interno - 1519567 - FABIO FAGUNDES DA ROCHA
Interno - 386960 - WELLINGTON DA SILVA CORTES
Externo à Instituição - ELSON ALVES COSTA - UFG