Banca de QUALIFICAÇÃO: GABRIEL CARDOSO REIS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : GABRIEL CARDOSO REIS
DATE: 09/03/2023
TIME: 15:00
LOCAL: Google meet
TITLE:

ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF BIXA ORELLANA SEED EXTRACT. L IN MICE

KEY WORDS:

Keywords: Phytotherapy, Analgesia, Pain, Inflammation.

PAGES: 19
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Farmacologia e Terapêutica Animal
SUMMARY:

Pain is an extremely important sensation, as it allows awareness that the integrity of the organism is being threatened (FERREIRA et al., 2010). However, it can bring with it unpleasant consequences such as suffering, stress, damage to social and economic relationships, which is why it must be quickly and effectively controlled and treated (BRENNAN et al., 2007). Thus, the need to look for alternative measures in the development of drugs for pain control becomes remarkable. Some of the analgesic drugs, such as opioids and non-steroidal anti-inflammatory drugs, have their origins in natural products that have been used for thousands of years throughout the development of mankind. However, currently many of these plants are marketed as if they were extremely safe for consumption, as it is a natural source. But, while scientific research is not carried out, the pharmacological potential of these products is still questioned, and may not exist or even harm the individual who uses them (VEIGA JR and PINTO; 2005). In Brazil, the seeds, leaves and roots of Bixa orellana (Annatto) were popularly used as an aphrodisiac medicine, as well as a medicine to treat fevers, inflammatory conditions and parasitic diseases (DI STASI et al., 1989; PAUMGARTTEN et al., 2002) . Therefore, the objective of this work is to evaluate the antinociceptive and anti-inflammatory activity of Bixa orellana (Annatto) seed extracts. The specific objectives are: to evaluate the antinociceptive action of the extracts under conditions of acute pain; evaluate the anti-inflammatory activity of extracts under conditions of acute inflammation; to elucidate the mechanisms responsible for its antinociceptive and anti-inflammatory activities; evaluate the possibility of motor performance interference on the antinociceptive effect demonstrated by the extracts; and, finally, to evaluate the acute toxicity of the extracts.

COMMITTEE MEMBERS:
Presidente - 1674073 - BRUNO GUIMARAES MARINHO
Interna - 2193086 - MAGDA ALVES DE MEDEIROS
Externa à Instituição - RAQUEL DO NASCIMENTO DE SOUZA