Banca de DEFESA: MARÍLIA ALVES MACHADO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : MARÍLIA ALVES MACHADO
DATA : 23/03/2018
HORA: 08:00
LOCAL: Laboratório de Quimioterapia Experimental em Parasitologia Veterinária da UFRRJ
TÍTULO:

Safety and efficacy of afoxolaner for the treatment of otodectic mange (Otodectes cynotis) and control of fleas (Ctenocephalides felis felis) in felines

PALAVRAS-CHAVES:

dermatopathies, otoacariasis, puliciosis, therapy

PÁGINAS: 71
GRANDE ÁREA: Ciências Agrárias
ÁREA: Medicina Veterinária
RESUMO:

MACHADO, Marília Alves. Safety and efficacy of afoxolaner for the treatment of otodectic mange (Otodectes cynotis) and control of fleas (Ctenocephalides felis felis) in felines. 2018. Dissertation (Master's Degree in Veterinary Medicine, Clinical Sciences). Institute of Veterinary Medicine, Federal Rural University of Rio de Janeiro, Seropédica, RJ, 2018.

Three studies were carried out to evaluate the safety and efficacy of afoxolaner in the treatment of otoacariasis and flea control in felines: the first one to evaluate possible laboratory clinical adverse effects, 16 felines were used, they had the main physiological parameters monitored as well hemoglobin, hematocrit, platelets, total plasma proteins, neutrophils, eosinophils, monocytes, lymphocytes, urea, creatinine, phosphorus, albumin, ALT, and AST on days 7, +3, +10 and +31. No clinical or laboratory abnormalities were observed in the medicated animals. The second study to evaluate the efficacy of afoxolaner in the treatment of otoacariasis in felines, diagnosed through video-otoscopy. Sixteen felines were divided into two groups, with eight animals each, the first being untreated and the second treated with afoxolaner at a dose of 2.5 mg / kg in a single dose. The animals were evaluated at days -7, 0, +7, +14, +21, +28 and +35. At day +7 no more mites were observed in the auditory canal, different from the control group that remained with mites until day +35. The third study aimed to evaluate the efficacy of afoxolaner in the treatment of Ctenocephalides felis felis in artificially infested felines. Fourteen cats were divided into two groups with seven animals each, being the first control group without treatment and the second group treated with afoxolaner at a dose of 2,5 mg / kg in a single dose. Each animal was infested with 50 couples of fleas on days -2, +5, +12, +19, +, 26, +33, +40, +47, +54 and +63. The following formula was used to calculate the efficacy: Effectiveness percentage = (average number of live fleas recovered in the control group - mean number of live fleas recovered in the treated group) / (average number of live fleas recovered in the control group) x 100, where the mean number is represented by the arithmetic mean. After 48 hours the treatment showed 100% efficacy in the parasite control, remaining in 98.2% efficacy until the 42nd day. It is concluded that afoxolaner is an effective drug in the control of O. cynotis and C. felis felis in cats, being a safe option in the treatment of these ectoparasites.

MEMBROS DA BANCA:
Externo à Instituição - ARY ELIAS ABOUD DUTRA - OUTRO
Presidente - 4563410 - JULIO ISRAEL FERNANDES
Externo à Instituição - LILIAN CRISTINA DE SOUSA OLIVEIRA BATISTA CIRNE - OUTRO