Banca de DEFESA: JACQUELINE BATISTA DE FREITAS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JACQUELINE BATISTA DE FREITAS
DATE: 25/06/2021
TIME: 08:00
LOCAL: Defesa pela modalidade remota
TITLE:

Study of Epidural Space Location in Rabbits (Oryctolagus cuniculus) with the Assistance of Peripheral Nerve Stimulator and Epidurographic Analysis for Regional Anesthetic Block

KEY WORDS:

anesthesia, epidurogram, iohexol, neurolocalizer.

PAGES: 57
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Anestesiologia Animal
SUMMARY:

Lumbosacral percutaneous puncture in rabbit (Oryctolagus cuniculus) for epidural anesthetic block is a challenge in contemporary anesthesia, because the anatomical and physiological peculiarities of the species require precision in epidural space and local anesthetic volume to reach the nervous segment. of interest to be blocked. Lumbosacral puncture with the aid of peripheral nerve stimulator in rabbits is feasible because it is already recommended in canines and felines. This neurolocalizer-guided epidural puncture aims to improve analgesic quality in these animals in view of various surgical demands such as: orchiectomy, ovariosalpingohisterectomy, nodulectomy and osteosynthesis. The epidurogram, a serial contrast radiograph, has helped in the analysis of solution dispersion through the epidural space. The study will be conducted on 12 adult New Zealand white rabbits, as approved by the ethics committee, following clinical evaluation and prior complementary examinations. The animals will be randomly and equitably distributed into two groups, and premedicated with ketamine IM (20 mg kg-1) and midazolam IM (1 mg kg-1); after induction with propofol IV (3 mg kg-1) and intubation orotracheal, will be maintained under general anesthesia with isoflurane dose effect diluted in 100% oxygen (1 L / min). The location of the epidural space, through the neurostimulator needle, will be due to the rabbit's tail movement at the minimum milliamperage value (mA) of the device in the closest approximation of the nervous tissue. The contrasting solution (iohexol) will be administered in group I (n = 6) under the formula: 0.05 ml per cm in length between occipital bone and first coccygeal vertebra (Loc), and in group II (n = 6) under the formula: 0.33 ml per kilogram body weight. Respiratory (f) and heart rate (HR), oxyhemoglobin saturation (SPO₂), oscillometric blood pressure (SBP / MBP / DBP), expired carbon dioxide (EtCO₂) and esophageal temperature (ET) will be assessed. The analysis of iohexol cranial migration will be performed by serial epidurography every 5 minutes. The aim of this study is to evaluate the efficacy of the lumbosacral epidural puncture technique with the peripheral nerve stimulator in rabbits, to determine the neurolocation electrical regime for the species and to determine the cranial limit of contrast medium migration in the epidural space at different volumes.

BANKING MEMBERS:
Presidente - 2318733 - DANIEL DE ALMEIDA BALTHAZAR
Externa ao Programa - 2221879 - CARLA FERNANDA PARANHOS DE MOURA CARVALHO
Externo à Instituição - CRISTIANO CHAVES PESSOA DA VEIGA - UFRRJ
Externo à Instituição - DOUGLAS DOS SANTOS E CASTRO - UNICAL
Externo à Instituição - FABIO OTERO ASCOLI - UFF