Banca de QUALIFICAÇÃO: GUSTAVO NUNES DE SANTANA CASTRO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : GUSTAVO NUNES DE SANTANA CASTRO
DATE: 26/11/2021
TIME: 09:00
LOCAL: Google meet
TITLE:

Evaluation of the anti-inflammatory and antinociceptive activities of the synthetic compound ((2S,6S)-6-ethyl-tetrahydro-2H-pyran-2-yl)methanol in mice

KEY WORDS:

Tetrahydropyran derivatives, acute inflammation, mice, cytokines, acute nociception.

PAGES: 15
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Farmacologia e Terapêutica Animal
SUMMARY:

In recent years, the main objective of research related to pain treatment has been to develop new substances with greater efficacy and less toxicity than currently available drugs, and which have a lower economic cost. Therefore, there has been a great interest of researchers in the development of drugs based on molecular improvement strategies. Inflammatory affections affect animals in a marked and progressive way, causing sometimes irreversible damage. Early therapeutic intervention and effective drugs to control symptoms and disease progression are essential for a positive prognosis. Inflammatory affections in Veterinary Medicine are commonly related to chronic pain, mobility impairment, dyspnea, diarrhea and intestinal malabsorption, which are related to a high degree of morbidity and mortality in the veterinary clinical routine. With this project, we intend to evaluate the activity of the compound ((2S,6S)-6-ethyl-tetrahydro-2H-pyran-2-yl)methanol, here called LS20, in relation to its analgesic and anti-inflammatory potential in models in vivo and in vitro, in addition to in vivo and in vitro toxicological evaluation for future clinical trials in companion animals and thus contributing to the development of pharmacology and veterinary therapy.

BANKING MEMBERS:
Interna - 2193086 - MAGDA ALVES DE MEDEIROS
Interno - 2181699 - PAULO DE TARSO LANDGRAF BOTTEON
Interna - 2606155 - VIVIAN DE ASSUNCAO NOGUEIRA CARVALHO