Banca de DEFESA: JOSE EDUARDO SILVEIRA COUTINHO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JOSE EDUARDO SILVEIRA COUTINHO
DATE: 25/07/2022
TIME: 09:00
LOCAL: Instituto de Veterinária
TITLE:

Retrospective investigation of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in bitches with pyometra: 128 cases (2017-2019).

KEY WORDS:

canine, sepsis, systemic inflammatory, imunossupression, organ dysfunction

PAGES: 53
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Pyometra is defined as a uterine infectious disease of common occurrence in bitches. This disease
often determines the development of sepsis, which, in turn, is defined as a life threatening organ
dysfunction that occurs from a dysregulated host response to an infection. The diagnosis of sepsis
is considered a challenge in Veterinary Medicine. RNL and RPL are two biomarkers that have
shown promising results as biomarkers of this syndrome in humans. The objective of this
retrospective study was to evaluate the utility of these ratios biomarkers of sepsis in bitches with
pyometra. The medical records the Veterinary Hospital of the Federal Rural University of Rio de
Janeiro were reviewd. Healthy bitches were admitted as a control group (C, n=95), and bitches
diagnosed with pyometra as “P group”. The bitches with pyometra were sub-allocated in the
subgroups “without sepsis” (PO), “with sepsis” (PS), “survivors of sepsis” (PO+SS), “survivors
of pyometra” (SS) and “death group” (SN ). Epidemiological variables (age and race), laboratory
variables (total leukocytes, neutrophils, band neutrophils, lymphocytes and platelets), NLR, PLR
and number of organ dysfunctions were compared between groups and subgroups. ROC curve
analyzes were performed to determine the accuracy of variables for diagnosing pyometra and
sepsis and for predicting death outcomes. Binary logistic regression analyzes were performed to
verify the association of variables with different diagnoses and outcomes. Age differed only
between C and P groups. Different leukocyte and platelet dynamics were observed between
groups and subgroups. The NLR varied only between bitches with and without pyometra, and
was not accurate in diagnosing sepsis and predicting death in bitches with pyometra. The PLR
varied between bitches with and without pyometra, with and without sepsis, and between
pyometra survivors and death group. However, it did not present diagnostic and prognostic
accuracy for sepsis and outcomes. The number of organ dysfunctions was shown to be an
important predictor of death in bitches with sepsis and with a high association with it. It was
concluded that the NLR and the PLR do not represent useful tools for the diagnosis of sepsis and
prediction of death in bitches with pyometra.

BANKING MEMBERS:
Presidente - 2210162 - CASSIA MARIA MOLINARO COELHO
Interno - 1151827 - BRUNO RICARDO SOARES ALBERIGI DA SILVA
Externo ao Programa - 1120060 - ALEXANDRE JOSE RODRIGUES BENDAS - UFRRJExterna à Instituição - ANDRESA GUIMARÃES